(527d) Microstructural Characterization and Dissolution Behavior of Drug/Semicrystalline Polymer Systems
AIChE Annual Meeting
2011
2011 Annual Meeting
Particle Technology Forum
Engineered Composite Particulate Systems for Pharmaceutical Active Ingredient Delivery
Wednesday, October 19, 2011 - 1:30pm to 1:50pm
Time-resolved simultaneous small-angle X-ray scattering/wide-angle X-ray scattering (SAXS/WAXS) and second harmonic generation (SHG) microscopy has been employed to study the crystallization kinetics and structural evolution of drug/polymer systems. It was found that the drug formed larger crystallites at higher crystallization temperatures, and the overall crystallization kinetics seems slower. The dissolution study showed that the samples crystallized at higher temperatures shows much slower dissolution rate with different dissolution mechanism, compared to that prepared at lower temperatures, which is consistent with the SHG microscopy results.