(45f) Combinatorial Chemistries for Reducing Protein Adhesion with Plasma Grafting

Gu, M., Rensselaer Polytechnic Institute
Kilduff, J., Rensselaer Polytechnic Institute
Anderson, D. G., Massachusetts Institute of Technology
Langer, R., Massachusetts Institute of Technology
Belfort, G., Rensselaer Polytechnic Institute

We describe here for the first time a new combinatorial approach for synthesizing a wide range of surface chemistries with the aim of searching for reduced protein adhesion.  In order to speed up the search, screening and selection procedure, we have utilized our novel high throughput platform (HTP) with atmospheric pressure plasma-induced graft polymerization (APPGP) to modify synthetic commercial membranes (poly(ether sulfone) PES).  Monomers are first added to the porous polymeric film and then grafted polymerization was performed.  Previously discovered monomers (poly(ethylene glycol) (PEG) and zwitterionic (Zwit) that exhibit protein-resistance were selected and so were new ones discovered.  Many of these newly discovered monomers appear to have potential for reducing protein adhesion.