(3ci) Immuno-Liposome Nanoparticles for Single Cell Array | AIChE

(3ci) Immuno-Liposome Nanoparticles for Single Cell Array


Kwak, K. J. - Presenter, The Ohio State University

Immuno-Liposome Nanoparticles for Single Cell Array

Kwang Joo Kwak1,2


1NSF Nanoscale Science and Engineering
Center for Affordable Nanoengineering of Polymeric Biomedical Device

2Department of Chemical and Biomolecular

The Ohio State
University, Columbus, Ohio 43210

*Contact author-
E-mail: kwak.63@osu.edu

Recent advances in biomimetic lipid
membranes provide opportunities to develop applications such as biosensing, gene/drug
delivery, and cellular recognition. My research interests are focused on tethered
immuno-liposome nanoparticles (t-ILNs) that can be conjugated on a planar
surface through a self-assembled monolayer of a thiolipid and modified with cell
adhesion molecules and therapeutic targeting antibodies. The multi-antibody
conjugated t-ILNs have been investigated to be able to isolate extremely rare
cells such as cancer stem cells from the whole human blood. The t-ILNs array
based on a centrifugal force has been demonstrated to improve sensitivity and
specificity of stem cell isolation by increasing the focal adhesion between cell
and the ILN surface and preventing non-specific binding on the interfaces. Novel t-ILN array based cell isolation
has higher potential for many other important biomedical applications such as
prognosis of cancer patients and monitoring targeted therapy.