(346f) Application of Core-Shell Fluorescent Nanoparticles with Magnetic and Plasmon Properties In Biotransport Studies and Photo-Ablation Cancer Therapy

Galvis, A. A., Universidad de los Andes
Reyes, J. R., Universidad de los Andes
Vargas, R. D., Universidad de los Andes
Alvarez, O., Universidad de Los Andes
Vargas, W. L., Universidad de los Andes

Bimetallic/bifunctional nanoparticles that exhibit a core-shell with precise control of size, morphology, surface chemistry, and assembly process of each component have been the focus of attention in recent years. These functional nanocomposite nanospheres possess a core of silica-protected magnetite particles and in situ growth of a thin solid shell using Au nanoparticles as seeds to template the growth of the outer layer, such nanoparticles provide, fluorescence, magnetic and plasmon functionalities. These unique nanostructures are a highly efficient platform for several applications.  In this work two applications of such materials will be discussed: transport in prototypical tissues and photo-ablation cancer therapy.

For tissue bio-distribution assays we have used fluorescent nanocomposite nanopheres with a monolayer of rhodamine encapsulated into the core of SiO2. A diffusion cell with pig skin as prototype tissue has been implemented to conduct the transport experiments. A model based on the concepts of anomalous diffusion and the analytic and numerical of solution of the time fractional diffusion equation (TFDE) has been implemented, for determining the sub-diffusion parameters that describe the transport in such complex media.

For the purpose of improving bio-distribution of the particles, and the “anti-cancer” drugs that they could potentially transport, we have studied the change in the diffusion, cytotoxicity, hemolytic activity, and genotoxicity; in emulsions of type (O/W) with dispersed Fe3O4- Fe2O3@SiO2@Au nanoparticles. Finally a preliminary study of the phothermal ablation activity of the Fe3O4-Fe2O3@SiO2@Au nanoparticles, will also be discussed.