(328c) A 'fully' Disposable Primary Recovery Step for Harvesting Mammalian Cell Culture Systems: Focus of Depth Filtration Technologies
AIChE Annual Meeting
2011
2011 Annual Meeting
Separations Division
Primary Recovery In Bioprocessing
Tuesday, October 18, 2011 - 1:10pm to 1:30pm
The advent of highly productive cell-culture processes for the production of recombinant proteins has driven smaller batch processing that provides opportunity for transforming conventional bioprocess trains into single-use operations. We will be discussing the implementation of a disposable primary recovery step using Depth filtration technologies for harvesting recombinant proteins from high cell density cell cultures containing mammalian cells. We will provide a technical overview of conventional Depth filtration performance capabilities and novel processing techniques including the pros and cons for implementing these clarification technologies