(243a) Mechanochemical Energy Transduction In Muscle Contraction

Coupling of the linear momentum balance with the biochemical cycle and a model of force-velocity link in the crossbridge cycle enables computation of the steady state and transient dynamics of muscle action. Some controversies remain in this topic. for instance, some authors include lattice compliance while some data show that lattice compliance does not lead to very geat differences in simuation results at the macro scale. Anothe issue is the extent to which calcium ion transient are required in modeling mechanical action versus using a rapid equilbrium model for these steps. The art of modeling these systems is to include enough complexity without introducing too much complexity.