(568v) Refilling Mechanism to Stabilize a Free-Floating Intraocular Capsule Drug Ring (CDR)

In 2009, 15.1 million cataracts were extracted and replaced with intraocular lenses (IOL). Because IOLs are smaller in diameter than natural lenses, there is real estate in the periphery of the IOL unused. The Capsule Drug Ring (CDR) is an implantable device that stores and releases drug inside the capsular bag in this unused periphery. The objective of the refilling mechanism is to stabilize a free-floating body to allow penetration through the refilling ports. Two ports at each ends of the CDR allow the reservoir to be refilled with bevacizumab (Avastin) every six months to one year. Avastin is an antivascular endothelial growth factor which inhibits blood vessel proliferation. The maximum width of the refilling mechanism is 23 gauge. The 23 gauge refilling device will constitute an inner 30 gauge needle which will penetrate the ports, injecting Avastin into the CDR reservoir. We intend to use either a latching, hook/lasso or suction mechanism to stabilize the device for refilling. The latching and hook/lasso mechanism will entail rotation complications. It currently appears that suction will be superior.