(49d) Regulation of the Recognition of Pattern Recognition Receptors by Nanoparticles

Authors: 
Chen, H. C. - Presenter, University of Washington
Shen, H. - Presenter, University of Washington


The general strategy of the innate immune system is to provide immediate defense against infection through the use of a limited number of pattern recognition receptors. These receptors are capable of recognizing and engaging with features that are unique to microbes. As a result of the recognition, the pathogen can be contained or eliminated through a variety of actions including the secretion of cytokines. The profile of cytokines is critical for the elimination of pathogens and the establishment of adaptive immunity. In this study, we aim to understand the recognition of pattern recognition receptors and mediate the profiles of cytokines by nanoparticles.