(437a) New Developments in Heat Transfer Scale Down and in-Situ FT-IR for Safe Scale up From the Lab to the Plant

?In today's world, the chemical and pharmaceutical industry faces major challenges, for instance: globalization, environmental and safety regulation, and shortening product life cycle and increase time pressure for commercial releases. Breakthroughs in process operations and modeling are necessary to achieve energy and material efficiency gains supporting shorter development and scale-up times and improving the environmental, safety and economical profile of chemical processes . Those breakthroughs are made possible thanks in part to the use of process analytical technologies and reactor systems optimally designed for real time in situ process monitoring and accurate control of processes, both in lab and plant scale. These breakthrough innovations are designed to safely develop a chemical synthesis route in less time, ensuring a robust and economic process that can be efficiently and safely scaled to manufacturing. This paper will present case studies exploring the use of heat transfer scale down in the RC1e calorimeter to simulate a plant reactor's heat removal and will demonstrate the use of in situ FT-IR as real time chemistry monitoring technique from lab to plant.