(311d) Top-Down Production of Drug Nanocrystals - Nanosuspension Stabilization, Miniaturization and Transformation Into Solid Products
AIChE Annual Meeting
2010
2010 Annual Meeting
Particle Technology Forum
Engineered Composite Particulate Systems for Pharmaceutical Active Ingredient Delivery
Tuesday, November 9, 2010 - 4:33pm to 4:57pm
In this presentation, a number of subtopics of crystalline drug nanosuspensions will be discussed. The main focus lies on (i) their physical stabilization, and (ii) spray-drying and freeze-drying processes for further transformation into solid products. For both, the conservation of the beneficial dissolution properties of the nanosuspensions is considered as a key evaluation criterion.
Relevant references:
[1] Van Eerdenbrugh B, Vermant J, Martens JA, Froyen L, Van Humbeeck J, Augustijns P, Van den Mooter G. 2009. A screening study of surface stabilization during the production of drug nanocrystals. J Pharm Sci. 98(6): 2091-2103.
[2] Van Eerdenbrugh B, Stuyven B, Froyen L, Van Humbeeck J, Martens JA, Augustijns P, Van den Mooter G. 2009. Downscaling drug nanosuspension production: processing aspects and physicochemical characterization. AAPS PharmSciTech. 10(1): 44-53.
[3] Van Eerdenbrugh B, Van den Mooter G, Augustijns P. 2008. Top-down production of drug nanocrystals: nanosuspension stabilization, miniaturization and transformation into solid products (mini-review). Int J Pharm. 364(1): 64-75.
[4] Van Eerdenbrugh B, Froyen L, Van Humbeeck J, Martens JA, Augustijns P, Van den Mooter G. 2008. Alternative matrix formers for nanosuspension solidification: Dissolution performance and X-ray microanalysis as an evaluation tool for powder dispersion. Eur J Pharm Sci. 35(4): 344-353.
[5] Van Eerdenbrugh B, Vercruysse S, Martens JA, Vermant J, Froyen L, Van Humbeeck J, Van den Mooter G, Augustijns P. 2008. Microcrystalline cellulose, a useful alternative for sucrose as a matrix former during freeze-drying of drug nanosuspensions - a case study with itraconazole. Eur J Pharm Biopharm. 70(2): 590-596.
[6] Van Eerdenbrugh B, Froyen L, Van Humbeeck J, Martens JA, Augustijns P, Van den Mooter G. 2008. Drying of crystalline drug nanosuspensions - the importance of surface hydrophobicity on dissolution behavior upon redispersion. Eur J Pharm Sci. 35(1-2): 127-135.
[7] Van Eerdenbrugh B, Froyen L, Martens JA, Blaton N, Augustijns P, Brewster M, Van den Mooter G. 2007. Characterization of physico-chemical properties and pharmaceutical performance of sucrose co-freeze-dried solid nanoparticulate powders of the anti-HIV agent loviride prepared by media milling. Int J Pharm. 338(1-2): 198-206.