(253e) Evaluation of the Microstructure of Semicrystalline Solid Dispersions

Authors: 
Zhu, Q., Purdue University
Taylor, L., Purdue University
Harris, M. T., Purdue University


As a result of an increase in the number of emerging therapies with dissolution limited bioavailability, formulation strategies such as solid dispersions[1] that enhance the rate of solubilization are of interest.[2-5] In this study, the microstructure of solid dispersions prepared with polyethylene glycol (PEG) and several model compounds with different physicochemical properties were evaluated using a variety of experimental techniques. Solid dispersions were prepared by fusion and evaluated using small angle X-ray scattering (SAXS), powder X-ray diffraction (PXRD) etc. SAXS results indicated that, aceclofenac and chlorpropamide solid dispersions favored the interlamellar aggregation of the drug in the PEG matrix. Optical microscopy did not show any evidence of interspherulitic accumulation for any of the model compounds. Haloperidol was highly crystalline in the dispersions, whereas evidence of amorphous material was found for the other model compounds. Results indicated that both the crystallization tendency of the drug and its solubility in amorphous regions of PEG played important roles in determining the aggregation mode and size range of the drug within the dispersion.

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