(62bb) Metabolic Analysis of Prostate Cancer

There is currently great opportunity to expand the knowledge of cancer in areas concerning the effect of altered protein expression on central metabolism. The proteome involved in energy usage for cell proliferation might have developed alterations so that it could accommodate the more rapid growth and development of cancer cells. The purpose of this project is to conduct a proteomic study on the cellular metabolic processes relevant to carcinogenesis and cancer propagation. Understanding the function of protein in metabolic networks will help develop more effective approaches to detection, monitoring, and treatment of cancer. A normal prostate cell line (control) has been be grown along with two prostate cancer cell lines, and from these cell lines, protein were extracted. The protein systems of interest, those that are associated with central metabolism, have been analyzed via two-dimensional gel analysis (2DGE). The results show that analysis with 2DGE promises great potential in diagnostic medicine.