(304c) An Aggregation Model for Flash NanoPrecipitation Conference: AIChE Annual MeetingYear: 2009Proceeding: 2009 AIChE Annual MeetingGroup: Particle Technology ForumSession: Dynamics and Modeling of Particles, Crystals and Agglomerate Formation Time: Tuesday, November 10, 2009 - 3:55pm-4:15pm Authors: Cheng, C., Iowa State University Fox, R. O., Iowa State University Flash NanoPrecipitation is a novel approach for producing functional nanoparticles stabilized by amphiphilic block copolymers. A microscale multi-inlet vortex (MIV) reactor is utilized for this process because of its mixing performance and flexibility. During this process, the particle size distribution is frozen and stabilized by the amphiphilic di-block copolymer on the organic particle surface. That is, the particle growth is kinetically arrested and thus a narrow particle size distribution can be attained. To model the precipitation process, a bivariate population balance equation (PBE) has been formulated to account for co-precipitation of the organic and the block copolymer. Aggregation rate kernels have been derived to account for the major different aggregation events: free coupling, unimer insertion, and aggregate fusion. The resulting PBE is solved both by direct integration and by using the quadrature method of moments.