We are aware of an issue with certificate availability and are working diligently with the vendor to resolve. The vendor has indicated that, while users are unable to directly access their certificates, results are still being stored. Certificates will be available once the issue is resolved. Thank you for your patience.

(304c) An Aggregation Model for Flash NanoPrecipitation

Cheng, C., Iowa State University
Fox, R. O., Iowa State University

Flash NanoPrecipitation is a novel approach for producing functional nanoparticles stabilized

by amphiphilic block copolymers. A microscale multi-inlet vortex (MIV) reactor is utilized for

this process because of its mixing performance and flexibility. During this process, the particle

size distribution is frozen and stabilized by the amphiphilic di-block copolymer on the organic

particle surface. That is, the particle growth is kinetically arrested and thus a narrow particle

size distribution can be attained. To model the precipitation process, a bivariate population

balance equation (PBE) has been formulated to account for co-precipitation of the organic and the

block copolymer. Aggregation rate kernels have been derived to account for the major different

aggregation events: free coupling, unimer insertion, and aggregate fusion. The resulting PBE is

solved both by direct integration and by using the quadrature method of moments.