(376d) Understanding the Impact of Magnesium to Grignard Reaction Kinetic through on-Line Monitoring

Wong, S. W., Eli Lilly and Company
Singh, U., Eli Lilly and Company
LaPack, M. A., Eli Lilly and Company
Kopach, M. E., Eli Lilly and Company

Safety aspects of Grignard reactions are well documented; and PAT (Process Analytical Technology) has been utilized extensively for industrial processing. The presentation reports lab and pilot plant development efforts with a line of sight to manufacturing installation. Results using the Attenuated Total Reflection Fourier Transform Infrared (ATR-FTIR), NIR, and Raman spectroscopy are described along with the challenges encountered with each technology during scale-up. Additionally, the effect of particle size, mixing, and magnesium grade on reaction kinetics were measured on both the laboratry- and pilot plant scale.