(332p) Phase Inversion Temperature (Pit) Method Utilized Preparation Of O/w Nano-Emulsion By Microreactor System | AIChE

(332p) Phase Inversion Temperature (Pit) Method Utilized Preparation Of O/w Nano-Emulsion By Microreactor System

Authors 

Ono, T. - Presenter, Okayama University
Kubota, J. - Presenter, Okayama University
Kato, A. - Presenter, Okayama University


O/W Nano-emulsion was successfully prepared by applying microreactor system in water/polyethylene glycol dodecyl ether (C12E4)/dodecane system by the phase inversion temperature method. Nano-emulsification was carried out by combining two consecutive microreactors. Initially, relatively large droplets were prepared in Y-shaped microchannel as pre-emulsification with distilled water as the continuous phase (flow rate; 100 µl/min.) and 20 wt% C12E4-80 wt% dodecane solution as the disperse phase (flow rate; 40 µl/min.). Immediately after that, prepared pre-emulsion was heated up to 333 K by passing through in a tubular microreactor. According to the standard recipe, time required to heat up at 333 K was measured to be 12.6 s. Heated solution was then cooled by air (298 K) to obtain nano-emulsion (droplet diameter; ca 100 nm, measured by dynamic light scattering (DLS)). Stability of the nano-emulsion was also investigated by measurement of the droplet diameter as a function of time. The results showed that the droplet diameter slightly increased from 90 to 120 nm with the elapse of time (up to 100 h). Furthermore, the noble estimation procedure was confirmed to design the suitable microreactor for nano-emulsification by the phase inversion temperature method. These investigations show the great potential for continuously preparing the monodispersed nano-emulsion, and can be expected to apply the pharmaceutical and cosmetic field.