(586c) Nanoparticles for Targeted Delivery to Prostate Cancer Cells

Authors: 
Radovic-Moreno, A. F. - Presenter, Massachusetts Institute of Technology
Farokhzad, O. C. - Presenter, Harvard Medical School
Teply, B. A. - Presenter, Massachusetts Institute of Technology
Fuller, J. - Presenter, Massachusetts Institute of Technology
Gu, F. - Presenter, Massachusetts Institute of Technology
Langer, R. - Presenter, Massachusetts Institute of Technology
Levy-Nissenbaum, E. - Presenter, Massachusetts Institute of Technology


There is a need for the development of cell-, or tissue-specific delivery vehicles for cancer therapeutic and diagostic applications. Targeted nanoparticle formulations have been identified as one possible method for achieving the required specificity, leading to an exponential rise in the number of reports in the literature based on these technologies. We hypothesized that a systematic approach for optimizing the biochemical and physical properties of these vehicles may speed their translation to the clinic. Herein, we report the development and evaluation of an array of poly(D,L-lactide)-b-poly(ethylene glycol) nanoparticles as a tool for targeted delivery optimization.