(577a) Segmented Poly(Ester Urethane)Urea Elastomers with Biodegradable Hard and Soft Segments
AIChE Annual Meeting
Thursday, November 16, 2006 - 3:15pm to 3:36pm
Tissue engineering is an attractive approach to address the growing need for clinically effective materials that requires the creation of constructs capable of stimulating integration, vascular infiltration, and remodeling. We postulate that the mechanical properties of the biomaterial scaffold are an important design criterion and must be tuned to the requirements of the target tissue. For the goal of regenerating bone, we have undertaken the synthesis of a family of novel biocompatible segmented poly(ester urethane)ureas with biodegradable hard and soft segments. Our polyurethanes consist of a poly(epsilon-caprolactone-co-glycolide-co-DL-lactide) (PCL) macrodiol soft segment and a hard segment comprising 1,6-diisocyanatohexane (HDI) and a 1,3-propanediol bis(4-aminobenzoate) (PABA.PDO.PABA) chain extender. Differences in polarity between the hard and soft segments promote microphase separation. Hydrogen bonding between urea groups in the hard segments of adjacent polymer chains promotes hard segment ordering, thereby increasing the modulus of the material. By systematically varying the polyester macrodiol molecular weight and the polymer stoichiometry, we can achieve a family of polymers with similar chemistries but with different mechanical properties due to differences in hard segment content and the degree of microphase separation and percolation.
We present initial chemical, physical, and biologic analyses of our poly(ester urethane)ureas. Polymers were analyzed by proton NMR and GPC to determine hard segment content and molecular weight, respectively. Polymer films for dynamic mechanical and tensile experiments were prepared by solvent-casting. Finally, proliferation and osteoblastic differentiation of bone marrow stromal cells were measured on polymer films. Our results demonstrate that polymers support attachment of osteoprogenitor cells and have tensile strengths in the range of 50 MPa.