(165a) Electrochemical Sensor for Toxic Chemicals Based on Nanodeposit and Enzyme Conference: AIChE Annual MeetingYear: 2006Proceeding: 2006 AIChE Annual MeetingGroup: BionanotechnologySession: (22b) Nanotechnology and Nanobiotechnology for Sensors I Time: Tuesday, November 14, 2006 - 8:30am-8:50am Authors: Oh, I., University of Illinois at Urbana-Champaign Monty, C. N., The University of Akron Masel, R. I., University of Illinois at Urbana-Champaign There are strong demands for sensors of toxic chemicals such as organophosphate (OP) and cyanide. One of the approaches for high-selectivity sensor is to utilize a specific chemical or biological interaction of the target molecule. Recently, we showed that the electrochemical sensor based on oxime chemistry has high selectivity, in which keto-oxime reacts with OP toxins and produces cyanide which is detected electrochemically. One of the bottlenecks in detecting an ultra-low level of toxic chemicals is the detection limit of the sensing electrode. We take two approaches to build a highly sensitive and selective sensing electrode. (1) Several silver-based materials are evaluated and optimized, such as silver nanodeposits on graphite or nanoporous silver membrane, which would show better performance than bulk electrode. (2) Enzyme-based sensing scheme is utilized, which would show inherently high chemical selectivity toward the target molecules.