(289af) Microwave-Assisted Synthesis of Racemic Α-Hydroxy Acids | AIChE

(289af) Microwave-Assisted Synthesis of Racemic Α-Hydroxy Acids

Authors 

Yu, H. - Presenter, Southern Yangtze University
Tan, B. - Presenter, The Ohio State University
Wu, J. - Presenter, Southern Yangtze University




Sodium trichloroacetic (NTCA) can be converted to α-hydroxy acids in a good overall yield by microwave-assisted phase transfer catalysis. All processes involving the catalyzed reaction of NTCA with aldehydes in the presence of tetrabutylammonium bromide (TBBA) followed by hydrolysis are completed in a reactor placed in a 650W microwave oven. RCH(OH)CCl3 (R:PhCH2CH2, PhCH:CH, PhCH3CH2CH2CH2, etc.) are prepared from RCHO, NTCA and TBBA in water and chloroform, then are hydrolyzed with sodium hydroxide directly added to previous vessel to form RCH(OH)COOH.

----------------------------------------------------------------------------------------------------------------------------- corresponding author: Yun FANG

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