(142q) A Novel Application of Solubility Parameter in Extraction of Bioactive Substances from Natural Products
AIChE Annual Meeting
2005
2005 Annual Meeting
Materials Engineering and Sciences Division
MESD Poster Session
Monday, October 31, 2005 - 6:00pm to 8:30pm
Using solubility parameter the solvent power of water-alcohol binary mixtures to extract the bio-ingredients from natural products was depicted. Practically, the extracted ingredients of polyphenols active to the radical scavenging and tyrosinase inhibition depended unpredictably on the solvent composition of water-alcohol mixtures. As such, in case of water-methanol the optimum extraction of polyphenols from Sophora japonica occurred at 60% of alcohol composition, at 80% in case of water-ethanol mixture, at 60% in case of water-n-propanol and at 40% in case of water-isopropanol . In addition, the bio-activities of the extractives such as radical scavenging and tyrosinase inhibitory effects were complicatedly varied with the water-alcohol mixtures and their compositions. However, when applying the solubility parameters indicating the polarity of the solvent mixtures, the solvent powers to extract the bio-ingredients at various water-alcohol mixtures and alcohol compositions could be simply expressed and the optimum solvent conditions for maximum extraction of the bio-ingredient could be easily predicted. It was also proven that such parameter was well applicable to bio-ingredient extractions from various natural products of Armeniacae Semen and Glycyrrhiza uralensis.
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