Mixture DOE and Design Space

  • Type:
    Conference Presentation
  • Conference Type:
    AIChE Annual Meeting
  • Presentation Date:
    November 10, 2010
  • Skill Level:
  • PDHs:

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Present a case study on mixture DOE involving five components used to formulate a pharmaceutical tablet. The goal is to achieve a sustained release by optimizing the concentration of a hydrophilic polymer in relation to the proportions of a drug and three excipients. Four responses (two related to release) are measured and modeled. Then numeric and graphical optimization are used to define a design space.
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