(337g) Integrated Formulation and Process Design for 3D Printing of Pharmaceuticals
AIChE Annual Meeting
Tuesday, November 15, 2022 - 2:36pm to 2:57pm
This study seeks to build an integrated PPD framework for a pharmaceutical 3D printing platform â Drop on demand (DoD) printing. DoD is a versatile inkjet 3DP that has been demonstrated to produce precise, personalized dosages for a variety of pharmaceutical formulations.6,7 It also supports integration with upstream active ingredient synthesis steps and has been demonstrated to function as a drug product manufacturing unit of a continuous mini-plant.2 Drug loading in the dosages produced by DoD need to be tightly controlled. Thus, the functionality desired in DoD is high printing consistency which is achieved when the drops generated have low variance in volume and have a low number of satellite drops. Printing consistency depends on both, formulation (product) properties like composition, viscosity, surface tension etc. and printing (process) conditions like drop ejection frequency, ejection pulse amplitude etc. For a novel formulation, the input (formulation and printing) conditions that give high printing consistency are conventionally determined experimentally. The PPD framework reported in this paper seeks to automate this process thereby engendering savings in time and material consumed.
To develop this framework however, a process model needs to be built to determine printing consistency for given input conditions. Theoretical studies modelling drop formation (occurrence of satellite drops, uniformity of drops generated etc.) in inkjets tend to focus on Newtonian fluid systems, however these cannot be directly applied to pharmaceutical suspensions where non-idealities such as polymeric carrier fluids and concentrated particle suspensions are frequently involved. Data driven approaches like machine learning can provide an alternate means to model the DoD printer.8,9 There is a plethora of machine learning techniques available to model process operations, artificial neural networks are one of the most widely used among them.
Thus, as a prerequisite to building the PPD framework, this study seeks to develop a neural network based machine learning model for DoD. This model will predict a printing consistency metric for a given set of input conditions. To build this model, experimental data is generated for a variety of formulation and printing conditions. This model is then applied to build the PPD framework and answer the question: to achieve high printing consistency, what printing and formulation properties can be used. Data driven models give only a one-way relationship between the input variables and the output. This makes solving the inverse estimation problem challenging as specifying output (printing consistency) does not enable calculation of input conditions. To overcome this a two-stage approach is proposed: first, points in the input design space are sampled using a broad sampling scheme such as Latin hypercube. The model is evaluated at the sampled points, input conditions that give high printing consistency are then screened and used as input to the next stage. In the second stage, a series of heuristics are applied to select the most desirable solution from this set (figure 1).
In this paper we will demonstrate that this two-step approach can form an effective basis for a PPD framework for DoD that can automatically determine optimal formulation and printing conditions for manufacturing dosages of any given drug.
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