(318c) Microcrystalline Cellulose from Soybean Hull As an Excipient for Solid Dosage Forms: Powder Characterization and Tableting Properties
AIChE Annual Meeting
2022 Annual Meeting
Forest and Plant Bioproducts Division
Advanced Separations Processes in Bioprocessing and Biomaterials
Tuesday, November 15, 2022 - 12:30pm to 12:45pm
Microcrystalline cellulose (MCC) is one of the most widely used binders in the formulation of oral suspensions and lotions, oral tablets, and capsules due to its chemical purity, non-toxicity, biodegradability, superior disintegrating property, and greater flowability. According to a market study conducted by Future Market Insights (FMI), the market for MCC will grow at a steady annual rate of 4.7%, topping US$ 818 million in 2028. Among all the markets mentioned above, the pharmaceutical industry dominates the global MCC demand with about 40 percent market share, most of which can be attributed to its role as the direct compression (DC) binder in oral tablet manufacturing.
In this study, we have produced SBH-based MCC as an alternative to wood-based commercial MCC (Avicel®). The processing stages include acid pretreatment followed by filtering and washing, alkali pulping, and chlorine dioxide bleaching. The filtrate from the acid treatment stage can be used in producing biopolymer-based (rich in protein and pectin) coatings and films. This integrated approach will produce a by-product while decreasing the amount of effluent produced. SBH-based powders were tested and compared with Avicel MCC powders for their thermal properties (TGA), structural and morphological properties (XRD and SEM), chemical composition (HPLC), density, and flowability (tap density tester, pycnometer, and angle of repose), and surface area (BET). The powders were then incorporated as the main component (60%) of excipient-only tablets comprised of lactose, sodium starch glycolate, and magnesium stearate. The quality and properties of the produced SBH MCC tablets (hardness, tensile strength, and disintegration) were tested and compared to the Avicel MCC tablets. Based on the results, we concluded that the SBH-based MCC can be a potential alternative for industrial scale tablet production.