(207d) Systematic Control Strategy Development for a Continuous Direct Compaction Line Via the Control Strategy Evaluation Tool (CET)
AIChE Annual Meeting
Monday, November 14, 2022 - 4:33pm to 4:54pm
Any change in material attributes (e.g., due to a change of raw material batch) or process settings (e.g., due to an adjustment of the mass flow rate through the manufacturing line) can also change the RTD and affect the discharge decision. Therefore, a comprehensive knowledge of the critical factors and their impact on the RTD is essential during control strategy development. Because an extensive experimental characterization of the RTD is often not feasible, a simulation based on the discrete-element-method (DEM) is adopted. The RTD obtained from the DEM simulations at selected process settings or for specified material attributes is then approximated by suitable reduced order models and interpolation techniques, which significantly reduce the computational cost needed for a real time control strategy.
Finally, a control strategy evaluation tool (CET) is introduced, which has the functionality to test material discharge strategies in a systematic manner without running costly experiments. Three main components of the CET include: i) a modular simulation model of pharmaceutical manufacturing lines based on the RTD models mentioned above, ii) a library of typical disturbance scenarios, and iii) a discharge algorithm that implements a certain control strategy in terms of material discharge. The functionality of the CET is demonstrated using selected scenarios.
Disclaimer: This abstract reflects the views of the authors and should not be constructed to represent FDAâs views or policies.