(742d) Nanoencapsulation of Cannabidiol Via Flash Nanoprecipitation with Naturally Derived Polymer Stabilizers
AIChE Annual Meeting
Thursday, November 18, 2021 - 8:36am to 8:54am
Here, we investigate the encapsulation of cannabidiol (CBD) as a model drug. CBD in its amorphous state has a low glass transition temperature and at ambient temperature exists as a nonaqueous liquid. We show that amorphous CBD can be effectively encapsulated into nanoparticles with low polydispersity and high drug loading via Flash NanoPrecipitation, a scalable self-assembly process. Two naturally derived polymers, HPMCAS and lecithin, are employed as amphiphilic particle stabilizers. The resulting nanoparticle suspensions are size stable over time and are thus suitable for further downstream processing. Lastly, we show that the nanoparticle formulation can enhance the release rate of CBD in vitro, and the release rate may be tuned by varying the particle properties.