(431g) Building an in silico Representation of the Tumor Microenvironment One Agent at a Time (Invited Speaker)
- Conference: AIChE Annual Meeting
- Year: 2021
- Proceeding: 2021 Annual Meeting
- Group: Food, Pharmaceutical & Bioengineering Division
- Time: Wednesday, November 10, 2021 - 9:48am-10:28am
In this presentation, I introduce a multiscale agent-based model of a generic tumor microenvironment. This model integrates subcellular signaling and metabolism, cellular level decision processes, and dynamic vascular architecture and function to interrogate multilateral regulation among heterogeneous cell agents in a nascent solid tumor. Using this framework, we interrogate emergent dynamics of tumor growth as a function of vascular architecture, cell heterogeneity, nutrient distribution, and immune intervention. In addition to the tumor microenvironment, this flexible model framework can be adapted to represent and analyze a wide variety of cell contexts, including wound healing and stem cell colony formation and fate commitment.