(356c) Evaluation of Solid-Liquid Equilibria for Drug + Water + Cyclodexstrins System Using Activity Coefficient Models

Drug candidates with strong pharmacological activity have increasingly been developed using combinatorial chemistry and high-throughput screening. As a result of these screening methods, the number of drugs with decreased water solubilities has increased due to higher molecular weights and more complicated chemical structures. Therefore, the co-solvents are commonly used in the pharmaceutical industry in order to increase the solubility of relatively water insoluble drugs.

Some predictive methods in order to predict the solubilities of drugs using activity coefficient models have been proposed [1]. But the paper in case that co-solvent is solid may be quite few.

This paper deals with the evaluation of solubility for drug + water + solid co-solvent system using activity coefficient models. The drugs treated in this paper are famotidine and etodolac, and the co-solvents are α-cyclodexstrin and β-cyclodexstrin [2, 3]. The activity coefficient models are Wilson and Wilson + Porter equations [4].

References

[1] H. Matsuda, K. Kaburagi, K. Kurihara, K. Tochigi and K. Tomono, Fluid Phase Equilibria, 290 (2010) 153-157.

[2] H. Matsuda, S. Matsumoto, K. Kaburagi, K. Kurihara, K. Tochigi and K. Tomono, Fluid Phase Equilibria, 302 (2011) 115-122.

[3] Y. Naito, H. Matsuda, K. Shimomura, K. Kurihara, K. Tochigi and K. Tomono,Fluid Phase Equilibria, 357 (2013)43-49.

[4] H. Matsuda, K. Tochigi, K. Kurihara, T. Funazukuri and V.K. Rattan, Fluid Phase Equilibria, 492 (2019) 137-144.