(9e) A Microfluidic Model to Assess Subcutaneous Transport and Pharmacokinetics in Vitro
AIChE Annual Meeting
Monday, November 16, 2020 - 8:45am to 9:00am
Our microfluidic device incorporates critical elements of the subcutaneous space including multiple relevant cell types and vascular flow. Transport properties measured in this device can be translated to pharmacokinetics obtained from in vivo studies. We validated that the measured diffusivities in our device are on the same order of magnitude as those measured in vivo. We were able to capture the effects of molecular weight, shape and charge on the rate of subcutaneous diffusion. By changing cell types, we also compared data between human and mice subcutaneous environment. Our device demonstrates the potential of cellular microfluidic devices as a controlled and predictable means for studying drug transport in the subcutaneous space.