(98c) Effect of ALD and MLD Coating on Wetting and Flow Properties of Micron-Sized Inhalation Pharmaceutical Powders
- Conference: AIChE Annual Meeting
- Year: 2020
- Proceeding: 2020 Virtual AIChE Annual Meeting
- Group: Pharmaceutical Discovery, Development and Manufacturing Forum
- Time: Monday, November 16, 2020 - 8:30am-8:45am
Coating of powder material can be a solution to modify surface properties of individual particles, so as to improve wettability and flowability. Therefore, we experimentally coated the Budesonide powders (size range of 0.1 to 10 µm) with SiO2, TiO2, Al2O3 and PET (Polyethylene terephthalate) in a vibrated fluidized bed reactor. Nano-sized films of SiO2, TiO2, and Al2O3 was coated on the surface of Budesonide particles via atomic layer deposition (ALD, inorganic coatings). Nano-scaled layers of PET was deposited onto Budesonide via molecular layer deposition (MLD, organic coatings). The effects of different coating materials, coating cycles (thickness) and coating process (ALD and MLD) on the two important properties of Budesonide powders, wettability and flowability were investigated.
Uncoated Budesonide powder is classified as a very hydrophobic material with poor flowability. Improvements both in the wettability and flowability of Budesonide after the ALD coating process are observed. The coated Budesonide becomes less hydrophobic and its flow property improves; the degree of improvement depends on the coating material. The positive effect can be further enhanced by increasing the number of coating cycles. In particular, Budesonide coated with TiO2 shows the largest increase in wettability (smallest water contact angle). In contrast to ALD coated Budesonide, PET coated budesonide via MLD becomes more hydrophobic compared to the uncoated Budesonide.