(654d) Engineering Protein-Based Biomaterials for Stem Cell Differentiation
AIChE Annual Meeting
2020
2020 Virtual AIChE Annual Meeting
Regenerative Engineering Society
Regenerative Engineering: Biomaterials for Regulating Cell Function II
Friday, November 20, 2020 - 12:30pm to 12:45pm
For tissue engineering applications, our lab is developing protein-based biomaterials to promote mesenchymal stem cell differentiation towards particular cell fates (e.g., bone or cartilage). We have genetically engineered modular proteins containing peptides containing growth factors to promote bone differentiation. We recently developed hydrogels containing a blend of collagens I and II, and these hydrogels promote in vitro cartilage differentiation and in vivo cartilage repair. Overall, our work demonstrates that bioactive cues based on peptides or proteins can successfully promote adult stem cell differentiation to desired lineages.