(591d) Multipurpose Automated Optimization Platform for Reactions Involving Solids
AIChE Annual Meeting
Thursday, November 19, 2020 - 8:15am to 8:30am
We demonstrated the autonomous optimization of a Suzuki-Miyaura cross-coupling reaction involving solid substrates and catalysts in an automated flow platform comprising a CSTR cascade, slurries feeding pumps, and an inline HPLC. The hardware control and automation were achieved with an integration of LabVIEWTM,6 MATLAB®,7 and online analysis. This research-scale fully automated flow platform for reaction self-optimization with solids/slurries feeding and handling while consuming a reduced amount of raw materials facilitate identification of optimal reaction conditions for manufacturing process development.
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6. LabVIEWTM is a trademark of National Instruments. This publication is independent of National Instruments, which is not affiliated with the publisher or the author, and does not authorize, sponsor, endorse or otherwise approve this publication.
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