(26g) In silico Design Space Investigation of a Novel Tablet Coating Process Using Advanced Coupled Simulations
AIChE Annual Meeting
Monday, November 16, 2020 - 9:30am to 9:45am
Computational methods are increasingly used in the pharmaceutical industry as well and facilitate a deeper understanding of the process mechanics. The discrete element method (DEM) and computational fluid dynamics (CFD) are two methods that allow transition from empirical process design to a mechanistic understanding of the individual process units. This work used CFD-DEM simulations to increase the understanding of the ConsiGma® tablet coater through a multi-variant design study. The results are split into two categories: first, the tablet bed behavior (mechanics) will be investigated and second, the thermodynamically behavior will be studied.
The goal of this work is to present a comprehensive overview of the influence the varying process and material input parameters have on the process output responses. The simulations show how the drum load, rotation rate, and material properties all influence the tablet bed behavior. The same can be said that the drying air flow rate, spray rate, and inlet temperature can influence the coating quality which is tracked through the tablet temperature and wetness. Overall it could be shown that simulations allow for the full coating process to be recreated numerically which, in return, saves material and equipment time typically required for process development.