(158n) Self-assembly peptide-based micromotors controlled by 3D magnetic field for deep solid tumor

In vivo self-assembly peptides as important candidates are expected to be used in cancer treatment. The peptide is conducive to deep penetration since its unassembled state with a small size in vitro; when it penetrates into the solid tumor, self-assembly behavior occurs in the tumor microenvironment, which can enhance its accumulation and internalization. However, the initiative and selectivity of the nanodrugs are insufficient because of the lack of engine to overcome the limitations of natural physical movement in the body, resulting in poor drug effects and strong side effects.

Micro/nano-motor (MNM) is the revolutionary and innovative field to replace the current drug delivery system. MNM can convert chemical or external energy in the surrounding environment into mechanical kinetic energy to produce autonomous movement. After more than ten years of development, micro/nano-motors based on various structures, such as microtubes, microwires, and spiral micromotors have been developed. Due to the tiny structure and the ability of active propulsion, micro/nano-motors present more and more advantages in the field of active drug delivery. However, using MNM method to empower active peptide-based nanodrugs have not been studied.

This work firstly suggested the peptide-based microrobots used for active drug delivery. The active engine was mounted on the peptide drugs by magnetic particles to enable its active movements in complex body fluid environments under the control of external magnetic fields to enhance its mobility. Rapid aggregation and self-assembly of drug peptides at the target site were achieved. In this work, peptide is used as the base of propulsion for micromotors for the first time, which provides a new view for active motion on the level of peptide.