(121g) Development and Process Intensification of a Three Step Continuous Flow Process for Telescoped High Energy Reactions

Continuous manufacturing (CM) offers significant advantages over traditional batch manufacturing for chemistries that generate or require high energy (usually in the form of heat). The comparatively large surface-area-to-volume ratio of flow reactors makes them particularly attractive for chemical reactions such as lithiation-carboxylation, nitro reduction, debenzylation, and thermal cyclization. Continuous processing also allows the reaction rates for these transformations to be orders of magnitude higher than would be possible with batch manufacturing. Additionally, performing these reactions in flow allows them to be telescoped to reduce operator handling and processing downtime.

This presentation will focus on development and process intensification of a three step continuous flow process toward synthesis of an active pharmaceutical ingredient (API). It will detail how construction of fit-for-purpose continuous reactors improves safety, cost, and process mass intensity while enabling use of preferred reagents and unlocking otherwise unattainable operating conditions.