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The Role of PAT, Condition Monitoring and Adaptive Control in Delivering QbD

Oct 29, 2012
Steve Hammond
“The Role of PAT, Condition Monitoring and Adaptive Control in Delivering QbD” Stephen Hammond, Mark Smith, Pfizer Global Supply, Peapack NJ, USA The use of spectroscopic techniques such as NIR spectroscopy to deliver greater process understanding, either providing difficult to obtain compositional...

Modelling of a Filter Drying Process

Oct 29, 2012
Mark A. Pinto
Filter drying, also referred to as vacuum contact drying, is a process widely used in the pharmaceutical industry to remove water or organic solvents. The advantage of this process over other drying operations is that it can be used to dry solids that are sensitive to oxygen and temperature. The...

Exceptional Event Managemnt Applied to Continuous Pharmaceutical Manufacturing

Oct 29, 2012
Anshu Gupta
One of the important challenges in effective real time process management is the implementation of intelligent systems that can assist human operators in making supervisory control decisions, instead of simply sounding an alarm when process variables go out of range. Operator failures to exercise...

On the Selection of Ionic Liquids for the Conversion of Cellulosic Biomass Feedstock

Oct 29, 2012
Sameer Parvathikar
The use of ionic liquids (ILs) as solvents represents a promising route for the conversion of cellulosic biomass feedstock. 1,3-dialkylimidazolium ILs in particular, have become a popular and thoroughly-studied reaction media for this. Reactions such as the dissolution and hydrolysis of cellulose,...

A Shell-and-Tube Direct Steam Generator for Concentrated Solar Power Generation

Oct 29, 2012
Theodore Wiesner
?Making Solar Energy Economical? is one of the Grand Challenges posed by the National Academy of Engineering. However, innovation in concentrating solar power technologies (CSP) lags by considerable margins that of all other renewable energy technologies. The levelized cost of electricity (LCOE)...

A Model-Based Approach for the Construction of Design Spaces in Quality-by-Design

Oct 29, 2012
Richard D. Braatz
This presentation considers the characterization of the set of allowable real parameter uncertainties for the output of a nonlinear system to be located in a prespecified target range. This word “parameter” is used by FDA and in this presentation to refer to any variable held at a fixed value...

Scientific Validation of THz Spectroscopic Measurement and Its Pharmaceutical Process Analytical Technology (PAT) Applications: Case Studies of First Principles Modeling Approach

Oct 29, 2012
Huiquan Wu
As an emerging technology, THz spectroscopy has gained increasing attention in the pharmaceutical area during the last decade. This attention is due to the fact that (1) it provides a promising alternative approach for in-depth understanding of both intermolecular interaction among pharmaceutical...

Nuclear Energy: Is there a future after Fukushima?

Oct 29, 2012
Aris Candris
The future of the global nuclear energy industry, while certainly not without its challenges, remains vibrant. Even as the industry contends with near-record-low natural gas prices and the accident at Fukushima Daiichi, the reality is that global demand for electricity and concern over carbon...

Chemistry and Energy: Fortifying Our Historic Links

Oct 29, 2012
Gregory Babe
Centuries ago, early ideas were formulating that would advance the science of organic chemistry. Since its beginnings, there have been many organic chemistry milestones. They include in 1856, the discovery of a purple dye which helped usher in the modern organic chemistry industry. Henry Perkin, a...

Comparative Advantage - North American Manufacturing and the Shale Gas Century

Oct 29, 2012
David Porges
Over the long term, there are two fundamentals in North America's natural gas markets: 1. Supply will remain robust; and 2. Price will remain moderate and stable. This new-found, but likely durable, situation provides many opportunities to resuscitate the petrochemical industry in North America...

Modeling the Dynamics of the Film Coating Operation for Pharmaceutical Tablets

Oct 29, 2012
Salvador García-Muñoz
Previous work in understanding the thermodynamics of the film coating operation has focused mainly around the pseudo-steady state reached between the drying air and the cooling effect from the evaporation of the spraying solution [1]. The work presented here aims to mathematically describe the time...

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