Process Design & Development

Application of Quality by Design in API Process Development

Conference Presentation
AIChE Annual Meeting
Wednesday, October 31, 2012 - 2:45pm-3:00pm
Design of Experiments (DOE) is the most effective method to achieve product and pro­cess efficiency and optimization. Design of Experiment (DOE)...

A QbD Approach to the Process Development of Tofacitinib

Conference Presentation
AIChE Annual Meeting
Wednesday, October 31, 2012 - 1:15pm-1:30pm
Tofacitinib citrate (CP-690,550-10) is currently being evaluated for the treatment of rheumatoid arthritis, psoriasis and other diseases. An NDA has...

Dry Reforming of Methane Using Rh Substituted Pyrochlores

Conference Presentation
AIChE Annual Meeting
Wednesday, October 31, 2012 - 1:15pm-1:30pm
Dry (CO 2 ) reforming of methane (DRM) to syngas (H 2 and CO) has been well-studied over a number of catalysts. The high temperatures needed to...

Optimal Design of Transient Microreactor Experiments

Conference Presentation
AIChE Annual Meeting
Tuesday, October 30, 2012 - 12:30pm-1:00pm
Development of synthetic routes for active pharmaceutical ingredient (API) synthesis is increasingly performed using microreactors, because their use...

A Novel QbD Tool for Statistical Data Analysis

Conference Presentation
AIChE Annual Meeting
Tuesday, October 30, 2012 - 10:15am-10:30am
One of cornerstones of Quality by Design (QbD) is Design of Experiments (DoE). However, in addition to DoE, ICH Q8 (R2) recommends an enhanced...

Reducing CO2 Emissions From Refineries Through Chemistry Upgrade

Conference Presentation
AIChE Spring Meeting and Global Congress on Process Safety
Tuesday, April 3, 2012 - 12:00am
Despite the lack of a global greenhouse gas emission reduction agreement, regional schemes are moving forward to limit CO 2 and other GHG emissions...

Pressure Relief Valve Sizing Equations Basis

Archived Webinar
Mar 14, 2012
Engineers responsible for the sizing of pressure relief valves, will get a more in-depth understanding of the mathematical basis for the sizing...

Development of a Compact Fischer Tropsch Reactor

Conference Presentation
AIChE Annual Meeting
Tuesday, October 18, 2011 - 8:00pm
Fischer Tropsch (FT) synthesis is a polymerization process where a CH X species is added to a growing aliphatic chain. There are several models of...

The Cultivation of Algae and Its Conversion to Biodiesel

Conference Presentation
AIChE Annual Meeting
Tuesday, October 18, 2011 - 8:00pm
The Cultivation of Algae and its Conversion to Biodiesel Daniel Choi, Spencer Glantz, Jasmin Alsous, Warren D. Seider, Stuart W. Churchill Department...

Inline Mixing Device for Medical Applications

Conference Presentation
AIChE Annual Meeting
Tuesday, November 10, 2009 - 7:00pm
In the surgical field, the mixing of two combined fluid streams is required to form fibrin glue, used as a tissue sealant or a hemostat. The sealant...

Chemical Product Design

Archived Webinar
Sep 9, 2009
This webinar will be of particular benefit to industrial practitioners involved in the design of chemical products and processes, and faculty at...

Process Flow Diagrams

Archived Webinar
Jul 15, 2009
The webinar will benefit those inside and outside the process engineering community who need familiarity with PFDs as communication tools.

Biofuels Process Development

Conference Presentation
AIChE Spring Meeting and Global Congress on Process Safety
Tuesday, April 28, 2009 - 10:00am
Biofuels process development is exploding due to high crude oil prices, desire for energy independence, and government subsidy. Many challenges exist...

Kamlesh Bhatia: A Career In Innovation

Conference Presentation
AIChE Annual Meeting
Monday, November 17, 2008 - 7:00pm
We give an introduction and overview of the career of Dr. Kamlesh K. Bhatia, highlighting his major accomplishments and his influences on current and...

The Yoga of Process Development

Conference Presentation
AIChE Annual Meeting
Monday, November 17, 2008 - 7:00pm
Process Development is analogous to Yoga. It is a ‘Yoga' – a disciplined process for integrating the essential components to create a vision of the ‘...

Design and Process Control Issues In Nanomanufacturing

Conference Presentation
AIChE Annual Meeting
Monday, November 17, 2008 - 7:00pm
This presentation will raise awareness of some key process issues involved in answering the following primary question: in manufacturing products...

Success and Prospects in Process Systems

Conference Presentation
AIChE Annual Meeting
Sunday, November 16, 2008 - 7:00pm
Process Systems Engineering (PSE) has been at the core of chemical engineering's definition as a discipline since the earliest stages of its...

Video Tutorial: PFD Pump and Compressor Symbols

March 29, 2016
If you've ever confused a compressor for a turbine or expander while creating or reading a process flow diagram, then this post is for you. This short video tutorial from the...

Massive Porter Ranch Gas Leak a Cautionary Tale

February 12, 2016
Months of chaos, fear, and the smell of rotten eggs came to an end at Porter Ranch in Los Angeles on Thursday, once crews digging a relief well finally pierced the deep,...

Integrate Process Simulation and Process Synthesis

October
2005
Computational Methods
Dominic Chwan Yee Foo, Zainuddin Abdul Manan, Michael Lynn McGuire, Murugan Selvan
The design of a new process using computer simulations to analyze a process flowsheet based on the onion model can save time, effort and, ultimately, money.

Designing Dust Collectors

September
2011
Fluids and Solids Handling
Greg Mehos, P.E.
To assure reliable and safe operation of a dust collector, apply the basic principles of chute and hopper design — which are based on the dust's fundamental flow properties.

Video Tutorial: Basics of BFDs, PFDs, and PIDs

January 18, 2016
Confused about the differences between block flow diagrams (BFDs), process flow diagrams (PFDs), and piping and instrumentation diagrams (PIDs)? Then this tutorial is for you. And...

Bioreactor Design for Chemical Engineers

August
2011
Back To Basics
Gregory T. Benz
Fermentation processes are based on chemical engineering principles. Understand these concepts to achieve optimal bioreactor design.

Optimal Automated Process Fault Analysis

January, 2013
With this book as their guide, readers have a powerful new tool for ensuring the safety and reliability of any chemical processing system. It details a tested and proven strategy to develop optimal automated process fault analyzers.

Easy Ways to Improve Energy Efficiency

December
2012
Alan P. Rossiter, Veerasamy Venkatesan
Managing the energy consumption of a process does not need to be complicated. This article presents some examples of less-complicated strategies.

Follow this Process Development Path

December
2013
Reactions and Separations
Paul Szabo
Bench-scale engineering (BSE) and the interdisciplinary no-transfer team (INTT) are valuable complements to the scale-down-before-scale-up method of process development.

Designing Pneumatic Conveying Systems

May
2006
Fluids and Solids Handling
Eric Maynard
Use this 9-step methodology to design and operate a reliable and cost-effective system to efficiently transport materials.

Succeed at Process Integration

January
2004
Career Catalyst
Alan P. Rossiter
In the application of pinch analysis for energy efficiency improvement and process optimization, technical excellence is necessary and human interactions are important for project success.

Improve Energy Efficiency via Heat Integration

December
2010
Heat Transfer
Alan P. Rossiter
Process heat integration using pinch analysis is a respected tool for achieving energy efficiency. This article explains what pinch analysis is and how to use it in process design and operation to attain real-world energy efficiency gains.

Rapid Process Design

September
2006
Reactions and Separations
Professor Michael F. Doherty, Sagar B. Gadewar
Use this structured approach, which combines preliminary experimental data with predictive methods and heuristics, to quickly generate and screen process alternatives at the early stages of a new venture.

Handle Bulk Solids Safely and Effectively

September
2009
Fluids and Solids Handling
Eric Maynard, Greg Mehos and Eric Maynard
Follow these guidelines for proper design of bins, hoppers, and feeders to avoid operational and safety problems.

Making EHS an Integral Part of Process Design

June, 2001
This book presents an approach—termed MERITT (Maximizing EHS Returns by Integrating Tools and Talents)—for enhancing process development through better integration of environmental, health, and safety evaluations. It draws upon critical components of inherent safety, pollution prevention, green...

Guidelines for Process Safety in Batch Reaction Systems

September, 1999
Batch reaction systems pose unique challenges to process safety managers because they do not operate in a steady state. The sequence of processing steps, and frequent start-ups and shutdowns, increase the possibility of human errors and equipment failures. And, since batch plants are often designed...

Guidelines for Design Solutions for Process Equipment Failures

August, 1998
While there is no "perfect" solution or absolute zero risk, engineering design can significantly reduce risk potential in the CPI. In Guidelines for Design Solutions to Process Equipment Failures, industry experts offer their broad experience in identifying numerous solutions to the more common...

Applying the Paradigm Case Method for Flowmeter Selection

September
2006
Fluids and Solids Handling
Jesse Yoder
This effective approach to flowmeter selection involves a step-by-step method that begins by matching the application with the flowmeter(s). Then, a series of criteria are applied to narrow the selection.

Cost Management in Heat-Transfer-Fluid Systems

July
2006
Heat Transfer
Conrad E. Gamble, P.E.
By taking ownership of fluid-related decisions for the entire life of the project, from design through dismantling, users can secure the best and lowest-cost approach in process heating and cooling.

Designing Suspension-Mixing Systems

January
2006
Fluids and Solids Handling
Pavel Ditl, Frantisek Rieger
Impeller and vessel geometries are key factors in selecting mixing equipment to efficiently suspend particulate solids in slurries

Apply an Integrated Approach to Catalytic Process Design

February
2007
Reactions and Separations
Mitrajit Mukherjee, James Nehlsen, Richard V. Porcelli
To ensure a practical, efficient and economically viable process, first consider how a successful catalytic reaction system would work, then focus on making a catalyst with the desired characteristics.
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