Biological Engineering

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Society for Biological Engineering (SBE)

SBE is a global technological community that promotes the integration of engineering with biology and realize its benefits through bioprocessing, biomedical, and biomolecular applications. SBE provides opportunities for interaction of engineers and scientists, develops products and services bring value to the broad biological engineering community, and infuses awareness of biological engineering among all functions and activities of AIChE.

Forest Bioproducts Division (FBP)

The Forest Bioproducts Division promotes knowledge sharing and networking on topics dealing with products obtained from forest resources and other lignocellulosic materials.

AIChE Journal Highlight: An Engineering Roadmap for Biorefining

January
2013
Journal Highlight
In the January AIChE Journal Perspective article, “Engineering Biomass Conversion Processes: A Systems Perspective,” Univ. of Minnesota researchers Prodromos Daoutidis, W. Alex Marvin, Srinivas Rangarajan, and Ana Torres discuss the challenges,...

CEP: News Update

January
2013
News Update
Global Relationships Take Center Stage at the 2012 Annual Meeting; No Boiling Needed: Nanoparticles Convert Sunlight into Steam; Hydrogen Power Goes Mobile; Carbon Nanotubes Team Up with Graphene; New Process Brings Bendable Electronics Closer to Reality; and more.

SBE Update: The Merging of Bio and Nano

December
2012
SBE Special Section
June Wispelwey
Earlier this year, the Society for Biological Engineering (SBE) organized its Sixth International Conference on Bioengineering and Nanotechnology (ICBN), which focused on bio-nanoscience and bioengineering for translational medicine. The conference...

A MagDot-Nanoconveyor Assay Detects and Isolates Molecular Biomarkers

December
2012
SBE Special Section
Brandon Miller, Gang Ruan, Gregory B. Vieira, Jeffrey Chalmers, Jessica Winter, Kalpesh Mahajan, Maryam B. Lustberg, M.D., Ratnasingham Sooryakumar
The ability to quickly analyze, separate, and manipulate multiple types of biomarkers from small sample volumes is a significant step toward personalized medicine.

Engineered Protein Templates Synthesize Inorganic Nanomaterials

December
2012
SBE Special Section
Alia Schoen, Arunagirinathan Adhimoolam, David T. Schoen, Kelly N. L. Huggins, Sarah Heilshorn
This powerful biomimetic method is a fast, flexible way to produce a wide range of inorganic nanostructures from a single protein scaffold.

Engineering Complex Phenotypes in Industrial Strains

November, 2012
This book explains current trends and developments in engineering biocatalysts for the production of bulk chemical and biofuels from renewable biomass. The authors guide readers through the engineering of the complex traits and phenotypes needed for particular biocatalysts and bioprocesses.

CEP: News Update

November
2012
News Update
Magic Act: Electronics Disappear into their Surroundings; New Material Boasts World-Record Efficiency; Brain Cancer Studies Point to a Bio-Based Route to Nylon; Nickel Misbehaves in Li-ion Batteries, Solar Energy Gets Mixed Up

ONE-STEP FERMENTATIVE PRODUCTION OF POLYLACTIC ACID

May
2012
SBE Special Section
Min Kyung Kim , Sang Yup Lee, Si Jae Park
The use of PLA has been hindered by its complex and expensive synthesis process. A new technology promises to change this — giving PLA a chance to compete with fossil-based plastics.

Bio-Based Materials in the New Bio Economy

May
2012
SBE Special Section
Amar Mohanty, Manjusri Misra, Murali M. Reddy
Biological feedstocks are expected to gradually replace some fossil-based raw materials to create eco-friendly products, from car parts and packaging materials to electronic devices and other consumer goods - laying the foundation for a reduced-carbon economy.

CEP: News Update

October
2012
News Update
New Battery Takes Charge of its Power; Nanomaterial Reversibly Stores Hydrogen; Nanoparticles Sneak Past the Brain’s Armor ; and more

SYNTHETIC SPIDER SILK PROTEINS AND THREADS

May
2012
SBE Special Section
Axel H. Leimer, Lin Römer, Nathalie Mougin, Ute Slotta
E. coli can be genetically engineered to mimic the complex natural process by which a spider makes the proteins that it uses to spin the fibers for its web. With additional processing, fibers with properties similar to those of natural spider silk...

RHEOLOGICAL CHARACTERIZATION OF BIO-BASED MATERIALS

May
2012
SBE Special Section
D. Bhopatkar, O.H. Campanella, P.H.S. Santos
Experimental and analytical tools combined with computational studies can be used to design new bio-based materials tailored for specific applications.

CEP: News Update

September
2012
News Update
Slippery Surface Is Too Slick for Bacterial Films; New Materials Put the Brakes on Infection; ITO Flexes Its Muscles; Control Wrinkles with this Simple Method; and more

The Other Bio: Chemicals and Materials

May
2012
SBE Special Section
Miriam Cortes­ Caminero
Just in case you haven’t noticed, a new wave of biotechnology is underway. Over the last three decades, we have seen biological technologies used in therapeutics and agriculture. More recently, we have seen the use of biotechnology for industrial purposes.

CEP: Profile - Engineering Flavors and Bridging Cultures

August
2012
Profile
As the winner of a February 2012 episode of the Food Network’s Cupcake Wars, Winnette McIntosh Ambrose, a National Institute of Health scientist specializing in vision research, demonstrated that inspired chemical engineers can succeed in any realm — when they bring the right ingredients to the mix.

Bio-Based Materials Step into the Operating Room

September
2012
On The Horizon
Sujata K. Bhatia, M.D., P.E.
A new class of implantable medical materials — constructed from naturally derived and renewably sourced polymers — is poised to transform clinical medicine.

Systems Biology and Synthetic Biology

March, 2009
The genomic revolution has opened up systematic investigations and engineering designs for various life forms. Systems biology and synthetic biology are emerging as two complementary approaches, which embody the breakthrough in biology and invite application of engineering principles. Systems...

Engineering a Better Way to Heal Broken Bones

November
2010
SBE Special Section
Matthew B. Murphy
Integrating mesenchymal stem cells and biomaterials shows promise for treating traumatic skeletal injuries via bone tissue engineering.

Producing Fuels and Chemicals from Lignocellulosic Biomass

August
2008
SBE Special Section
Mark Holtzapple, Rocio Sierra, Aaron Smith, Cesar Granda and Mark T. Holtzapple
As oil and natural gas prices rise, lignocellulosic biomass becomes a viable feedstock for the fuel and chemical industries— provided key issues are addressed.

CEP: News Update

August
2012
News Update
Updates Include: The Natural Gas Debate Continues Smart Material Stays Cool in the Heat Firefly-Semiconductor Hybrid Lights Up Ionic Liquid Improves Hydrogen-Producing Catalyst One-Pot Synthesis Yields Zeolites at Bargain Prices High-Carbon Diet...

Developing Cell Therapy Biomanufacturing Processes

November
2010
SBE Special Section
Jon A. Rowley
Establishing scalable technology platforms that allow for varying levels of production throughout the different stages of clinical testing can minimize process development timelines, drug-comparability risks, and — ultimately — costs.

Applications in Drug Delivery and Tissue Engineering

February
2006
SBE Special Section
Ali Khademosseini, Robert Langer
Nanotechnology is an emerging field that could potentially make a major impact on human health. Nanomaterials promise to revolutionize medicine and are increasingly used in drug delivery or tissue engineering applications.

Using Genomic Tools to Improve the Production of Biologics

November
2009
SBE Special Section
Nitya M. Jacob, Wei-Shou Hu, Bernard Liat Wen Loo, and Miranda Yap , Wei-Shou Hu
Recombinant DNA technology transforms mammalian cells into factories for protein-based therapeutics. New techniques provide chemical engineers with a better understanding of the process as well as the cells themselves.

SBE Special Section - Industrial Biotechnology

October
2005
SBE Special Section
June Wispelwey
Student Chapters Have Arrived! SBE Frontier Tutorial Second Bioengineering and Nanotech Conference Michael Shuler Wins Inaugural James E. Bailey Award Fishing Out Unusual DNA Enzyme is Linked to Neurological Disease

Recombinant Protein Therapeutics from CHO Cells -- 20 Years and Counting

October
2007
SBE Special Section
Karthik P. Jayapal, Katie F Wlaschin, Wei-Shou Hu and Miranda G. S. Yap , Wei-Shou Hu
The CHO cell is at its height of technological prominence thanks to its adaptability to various culture conditions and plasticity in the context of genetic alterations. With further research, the application ofCell Culture Strategies based on...

The New Disposable Evolution

July
2009
SBE Special Section
Joanna Ziemlewski
Single-use systems have advanced from a limited product line to several new products for a wider range of unit operations. As these technologies evolve, new size, cost, and regulatory needs continue to fuel industry growth.

Biofiltration - A Primer

April
2001
Environmental Management
Stephen  F. Adler
Use these guidelines to scale up and design biofiltration processes for the control of volatile organic compounds.

QbD for Generic MR Drug Products

AIChE Annual Meeting
Oct 18, 2011
The Office of Generic Drugs ensures the therapeutic equivalence and quality of generic drug products. This is based principally upon a regulatory...

Quality by Design for Generic Drugs: Overview

AIChE Annual Meeting
Nov 7, 2010
Quality by design is an essential part of the modern approach to pharmaceutical quality. But there is uncertainty in the generic drug industry about...

Keys to Bioreactor Selection

March
2002
Reactions and Separations
John A. Williams
A few basic types of bioreactor designs are used to produce a wide range of products, from antibiotics to foods to fuels. Here's how to pick the best options for your application.

Stem Cell Engineering 101

November
2010
SBE Special Section
Jonathan Monk
Stem cells are poised to transform medical treatments for a host of diseases and malignant conditions. Translating stem cell research into clinical therapies, disease models, and drug-screening platforms will require a combination of sound science...

Avoid the Pitfalls of Bioprocess Development

August
2006
Process Development
Mukesh Doble
This article presents the challenges that an engineer might encounter when designing or scaling up bioprocesses and offers practical solutions, including those cited in literature.

Your Personal Genome for $1,000?

November
2009
SBE Special Section
IBM scientists from four fields — nanofabrication, microelectronics, physics and biology — are collaborating to develop a “DNA transistor” that could make obtaining a personalized genome analysis easier, faster, and cheaper — ultimately as low as $...

Biotransformations for a Green Future

October
2005
SBE Special Section
Susan Truesdell
Enzyme and microbial biotransformations offer green chemistry alternatives for performing difficult or non-selective chemical reactions.

Bioreactor Design for Chemical Engineers

August
2011
Back To Basics
Gregory T. Benz
Fermentation processes are based on chemical engineering principles. Understand these concepts to achieve optimal bioreactor design.

Deciphering the Mechanisms of Therapeutic Protein Production

October
2007
SBE Special Section
Christoph L. Bausch, Daniel W. Allison, Kevin J. Kayser, Matthew V. Caple, Trissa Borgschulte
Demand for therapeutic recombinant proteins will eventually exceed current production capabilities. This is a major driver in further understanding Chinese Hamster Ovary (CHO) cell biology, which is the cell line of choice for producing these...

Fermentation Goes Large-Scale

January
2003
Special Section
Alex Patist, Aristos Aristidou , J. J. Hahn , Pim van Hoek
Designing an economically competitive and environmentally sustainable fermentation route means considering the downstream separations needed to capture the final product during the initial process design.

Purifying Therapeutic Monoclonal Antibodies

May
2008
SBE Special Section
Amit Mehta, Amy Len, Benedicte Lebreton, Bradley Wolk, Jace Fogle, Martha Lovato Tse, Nuno Fontes, Robert van Reis, Roshan Shrestha
Eliminating the affinity chromatography step in the mAb purification process trims equipment requirements, shrinks the plant footprint— and reduces costs.

Principles of Bioprocess Control

November
2009
SBE Special Section
Joseph S. Alford
The use of complex living organisms, process variation, and lack of real-time measurements of key parameters are some of the challenges involved in automating a bioprocess. This article explains an indirect approach to monitoring and controlling a...

Enzyme Discovery: Screening, Cloning, Evolving

October
2005
SBE Special Section
Glenn Nedwin, Per Falholt, Thomas Schaefer
Enzymes are nature’s answer to many industrial and environmental challenges. This article details the latest approaches to enzyme discovery and evolution.

Biobutanol – A Replacement for Bioethanol?

August
2008
SBE Special Section
Ron Cascone
Ethanol, the leading incumbant biofuel, has several limitations.Butanol overcomes many of these, and holds promise as the next important transportation biofuel.

Integrating Single-Use Filtration Systems

January
2003
Special Section
Holly Haughney
Disposable filtration systems are gaiing popularity in the pharmaceutical arena. This article defines the equipment, specifications, applications and potential advantages of single-use filters and ancillary equipment.

Scaling Up Research to Commercial Manufacturing

November
2010
SBE Special Section
Erika Lapinskas
The production of stem-cell-based therapeutic products in large quantities is more complex than manufacturing molecular drugs. Scale-up and scale-out challenges arise related to the type of stem cell, cell expansion and banking, sterile handling,...

Mother Nature as both Doctor and Patient

November
2006
SBE Special Section
Edwin N. Lightfoot
Once we have grasped some essentials of this riotous, but surprisingly well ordered world, we shall find our transport phenomena background to have real utility.

The Role for Biofuels

March
2010
SBE Special Section
Carrie Atiyeh, Tim Eggeman
The advanced biofuels industry is at a critical stage of development and deployment.

Understand Discrete Nanoscale Transport

June
2008
On The Horizon
Anh-Tuan Dinh, Chinmay Pangarkar, Samir Mitragotri
Unlike mass, energy and momentum transfer, which are described by continuum equations, the movements and interactions of the nanoscale entitites within a cell constitute the transport phenomenon known as discrete nanoscale transport (DNT).

Consider Using Fluoropolymers in Biological Applications

December
2004
Materials
Lauri Jenkins, Sharon Libert, Victor Lusvardi
Even with the use of costly corrosion-resistant alloys, metal contamination continues to occur in the biologics industry, thus reducing product yield and activity. Fluoropolymers are emerging as a viable solution to this problem.
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