Biological Engineering

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From Biochemical Engineering to Synthetic Biology: A Short History of Engineering Impacts on Biotechnology

SBE Webinar

Sep 27, 2012

Harvey Blanch

This webinar will focus on how biochemical engineering developed in response to the need for large-scale production of antibiotics in the 1940s and 50s, even though fermentation provided a route to many industrial organic chemicals prior to their production from petroleum.

Society for Biological Engineering (SBE)

SBE is a global technological community that promotes the integration of engineering with biology and realize its benefits through bioprocessing, biomedical, and biomolecular applications. SBE provides opportunities for interaction of engineers and scientists, develops products and services bring value to the broad biological engineering community, and infuses awareness of biological engineering among all functions and activities of AIChE.

Food, Pharmaceutical & Bioengineering Division (FP & BE)

The FP&BE division coordinates AIChE's activities in the fields of food, pharmaceuticals, and bioengineering.

Forest Bioproducts Division (FBP)

The Forest Bioproducts Division promotes knowledge sharing and networking on topics dealing with products obtained from forest resources and other lignocellulosic materials.

PAT Application and Validation of Online Particle Sizing Measurement for Controlling a Critical Quality Attribute

Oct 18, 2011

Kevin J. Bittorf

In accordance with ICH Q8/9/10 and the FDA QbD initiative, companies are adding more and more PAT equipment, installing more sophisticated control systems, and moving to real-time release. Throughout this process, many questions have come to light. How is PAT justified for controlling quality...

The Role of Acidic Catalyst Support On the Catalytic Upgrading of Bio-Oils

Oct 18, 2011

Sunya Boonyasuwat

Catalytic conversion of bio-oil vapor has attracted considerable interest as a promising pathway for upgrading. In this work, the reaction of anisole and guaiacol, phenolic model compounds commonly existing in bio-oils, were studied over an acidic silica-alumina catalyst and at varying space times...

Cellulose Extraction From Rice Hulls Using Ionic Liquids

Oct 18, 2011

Charles J. Coronella

Over one fifth of calories consumed by humanity are from rice. Consequently, vast quantities of rice hulls are disposed of as waste, since the hull constitutes 20% of rice mass. Standard practice for disposal of rice hulls is burning, generating pollution and CO 2 , or thrown away in vast...

Mechanistic Models and Computer Software for Quality by Design In Formulation of Modified Release Dosage Forms

Oct 18, 2011

Xiao Yu Wu

Modified release dosage forms (MRDFs) can be designed and manufactured in various shapes and structures using different materials. Depending on the design, formulation and properties of drug and excipients (e.g. polymers), drug release from MRDFs can undergo varying mechanisms. In addition, the...

Cellobiose Hydrolysis Using Acid-Functionalized Nanoparticles

Oct 18, 2011

Leidy Peña

Mineral acids have been used effectively for the pretreatment of cellulosic biomass to improve sugar recovery and promote its conversion to ethanol; however, substantial capital investment is required to enable separation of the acid, and corrosion-resistant materials are necessary. Disposal and...

Effect of Column Temperature On HPLC Separation of Acetic Acid and Levulinic Acid

Oct 18, 2011

Rui Xie

High performance liquid chromatography (HPLC) is a routine method in the analysis of degradation products in the prehydrolysate or the hydrolysis liquor of lignocellulosic biomass. Cation exchange column chromatography with a metal counter ion has been used for the quantitative analysis of...

Co-Utilization of Methane In Steam-Biomass Gasification Using Concentrated Solar Energy

Oct 18, 2011

Aaron W. Palumbo

Presented is a novel gasification application where biomass is steam-gasified and natural gas is steam-reformed simultaneously in a solar reactor. Solar-driven gasification is a proven technology, and can augment the biofuel industry as a domestic fuel source. Gasification performed in an...

Modified AnoporeTM Hybrid Membranes for the Microfiltration of Cellulose Acid Hydrolysis Mixtures

Oct 18, 2011

Yong-Hong Zhao

Three classes of nonfouling substances, poly[poly(ethylene glycol) methyl ether methacrylate] (POEM), poly(sulfobetaine methacrylate) (PSBMA), and perfluoroalkyl tagged poly(ethylene glycol) surfactants (fPEG), were covalently tethered onto the surface of Anopore TM membranes (nominal pore size 0.2...

Heterogeneous Catalysts in the Dehydration of Fructose to HMF

Oct 18, 2011

Sylvia Reiche

Several crucial steps in the upgrading of biomass-derived raw materials involve acid catalyzed reactions, such as the hydrolysis of cellulose or the dehydration of sugars. Although heterogeneous catalysts are desired in large scale industrial processes, their application is limited by several...

Cellulase Inhibition by Pretreatment-Released Biomass Degradation Products

Oct 18, 2011

G. Peter van Walsum

The influence of pretreatment chemistry and the severity of dilute acid pretreatment on the subsequent enzymatic hydrolysis of soluble oligomer-derived and insoluble crystalline cellulose using a commercial enzyme preparation (Novozymes) was investigated. A dilute acid pretreatment was performed on...

Evaluation of Membrane Separations Opportunities within Lignocellulosic Biorefining Processes: Tailoring Membrane Properties

Oct 18, 2011

Jennifer M. Leberknight

Evaluation of Membrane Separations Opportunities within Lignocellulosic Biorefining Processes: Tailoring Membrane Properties Jennifer Leberknight, Amitkumar Gautam, and Todd J. Menkhaus South Dakota School of Mines and Technology Department of Chemical and Biological Engineering 501 East Saint...

Alkaline Deacylation of Corn Stover to Reduce Toxicity of Prehydrolyzates and Improve Enzymatic Hydrolysis

Oct 18, 2011

Urvi D. Kothari

Hydrolysates from dilute acid pretreatment of biomass contain various biomass degradation products which are inhibitory to enzymes and toxic to microorganisms. One of the main inhibitory compounds is acetic acid which is released from the lignin-hemicellulose matrix in the biomass. Acetic acid at...

QUALITY by Design (QBD), Biopharmaceutical Manufacture

Oct 17, 2011

Kurt Brorson

In the biopharmaceutical industry, consistently manufacturing a safe and high quality protein drug substance can be challenging. Recently, a regulatory structure supporting Quality by Design (QbD) for pharmaceuticals and biopharmaceuticals has been described in International Conference on...

Pyrolysis Vapors Upgrading Using Metal Oxides

Oct 17, 2011

Ayman Karim

Pyrolysis Vapors Upgrading using Metal Oxides Ayman M. Karim 1 , Donghai Mei 1 , Vanessa Lebarbier 1 , Changjun Liu 1,2 and Yong Wang 1,2 1 Pacific Northwest National Laboratory 2 Washington State University The vapors generated during fast pyrolysis of biomass contain a significant fraction of...

Role of Enzyme Blend Composition, Biomass Particle Size and Solids Loading On Pretreated Biomass Saccharification Efficiency

Oct 17, 2011

Shishir PS Chundawat

One of the limitations of screening enzyme combinations using microplate based assays (Gao et al. 2010, Bioresour Technol 101, 8:2770) is that these are typically carried out using milled biomass (1 mm). The crude glycosyl hydrolase mixtures were also analyzed using a high-throughput proteomics...

Milking Lipids From Green Alga: Feasibility of Using Biocompatible Solvents to Extract Lipids From Living Cells

Oct 17, 2011

Ryan Coiner

A key hurdle in realizing commercial-scale production of biodiesel from cultured algae is efficient harvesting/dewatering of algal cells. In order to produce a gallon of biodiesel from algae, thousands of gallons of water must be processed, even when algal biomass is grown in relatively...

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