Biological Engineering

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From Biochemical Engineering to Synthetic Biology: A Short History of Engineering Impacts on Biotechnology

SBE Webinar

Sep 27, 2012

Harvey Blanch

This webinar will focus on how biochemical engineering developed in response to the need for large-scale production of antibiotics in the 1940s and 50s, even though fermentation provided a route to many industrial organic chemicals prior to their production from petroleum.

Society for Biological Engineering (SBE)

SBE is a global technological community that promotes the integration of engineering with biology and realize its benefits through bioprocessing, biomedical, and biomolecular applications. SBE provides opportunities for interaction of engineers and scientists, develops products and services bring value to the broad biological engineering community, and infuses awareness of biological engineering among all functions and activities of AIChE.

Food, Pharmaceutical & Bioengineering Division (FP & BE)

The FP&BE division coordinates AIChE's activities in the fields of food, pharmaceuticals, and bioengineering.

Forest Bioproducts Division (FBP)

The Forest Bioproducts Division promotes knowledge sharing and networking on topics dealing with products obtained from forest resources and other lignocellulosic materials.

An Anaerobic Bacterial Treatment of Corn Stover to Prepare a Biorefining Feedstock

Oct 19, 2011

James MacLellan

Anaerobic Bacterial Treatment of Corn Stover to Prepare a Biorefining Feedstock James MacLellan, Zhengbo Yue, Robert Kraemer, Wei Liao* Department of Biosystems and Agricultural Engineering, Michigan State University East Lansing, Michigan 48823 Abstract The objective of this study is to apply an...

Change of Structure of Corncob with Dilute Acid and Lime Pretreatment and a Potential Process for Xylose Co-Production of Cellulosic Ethanol

Oct 19, 2011

Jihong Li

Degree of polymerization (DP) of cellulose is considered an important factor to effect on the conversion of Lignocellulose. The higher DP of cellulose, the more difficult conversion of lignocellulose is. In this study, corncobs were pretreated with dilute acid process for production of xylose, and...

Green and High Efficient Enzyme Hydrolysis Process for Sweet Sorghum Bagasse

Oct 19, 2011

Xinshu Zhuang

In order to improve enzymatic hydrolysis efficiency, several approaches including liquid hot water (LHW) pretreatment, adding surfactant, magnetic stirring and fed-batch hydrolysis were investigated, in which Sweet sorghum bagasse (SSB) was chosen as the feedstock. The experiment results showed...

Design Space Definition Using a Variational Bayes' Approximation

Oct 19, 2011

Linas Mockus

The design space may be interpreted as the constrained region of the key manufacturing parameters space which provides assurance of quality of a drug given that manufacturing occurs in this region. The metric used to represent this assurance should not be deterministic, rather it should be stated...

Incremental Disassembling of Woody Biomass and Production of Biochemicals

Oct 19, 2011

Shijie Liu

Woody biomass is a reliable renewable source of raw materials for energy and chemicals. Woody biomass is structurally composed of cellulose, lignin, hemicelluloses and other minor components. The compositions vary from species to species. The complexity / heterogeneity of woody biomass presents...

Managing Uncertainty In Design Space

Oct 19, 2011

Patrick J. Whitcomb

Design of experiments, followed by numeric and graphical optimization, is frequently used by engineers to optimize a process, and to define a design space or operating window. It is critical to understand the boundaries of this operating window – if you choose a specific set of operating conditions...

Design Space Verification for Tablet Dosage Form Using Modeling

Oct 19, 2011

Mary T. am Ende

Quality by Design principles are well established in the pharmaceutical industry. It is becoming common place to develop the design space for a drug product and include it in the regulatory filing. There are a broad range of methods to establish design space, some of which are focused on individual...

De-Risking Scale-up of a High Shear Wet Granulation Process Using Latent Variable Modeling and near Infrared Spectroscopy

Oct 18, 2011

Koji Muteki

In the development of wet granulated drug products, two primary sources of variance (disturbance) include the operational scale of the high shear wet granulation (HSWG) process and Active Pharmaceutical Ingredient (API) lot-to-lot variability, particularly for formulations containing a high drug...

Catalytic Isomerization/Dehydration of Sugars On Functionalized CNT-Metal Oxide Hybrids At the Liquid-Liquid Interface of Water/Oil Emulsions

Oct 18, 2011

Jimmy A. Faria

The conversion of C5-C6 sugars into 2-furfural (FA) and 5-hydroxymethylfurfural (HMF) have been considered as key intermediate step in the production of transportation fuels and chemicals from ligno-cellulosic biomass. Typically, the process involves the dehydration reaction of the sugars catalyze...

Improving Corn Stover Reactivity In Low Severity Pretreatment Through Deacetylation and Disc-Refining

Oct 18, 2011

Xiaowen Chen

The current “state-of-art” dilute acid pretreatment to produce bio-ethanol from corn stover requires severe conditions to overcome biomass recalcitrance, which, in turn, offers 70~80% xylose monomer yield and 5~7% furfural yield. However, high acid loadings and high reaction temperatures harm the...

Sub- and Supercritical Water Based Processes for Conversion of Algae Biomass to Fuels and Green Chemicals – A Review

Oct 18, 2011

Philip A. Marrone

Sub- and Supercritical Water Based Processes for Conversion of Algae Biomass to Fuels and Green Chemicals – A Review Philip A. Marrone and Bryan V. Yeh Science Applications International Corporation (SAIC) 60 Wells Ave, Suite 103 Newton, MA 02459 In recent years, there has been increasing...

Insights Into Lactate Metabolism Through Multivariate Analysis of Cell Culture Bioprocess Data

Oct 18, 2011

Huong Le

Multivariate data analysis has recently emerged as a critical tool to gain fundamental understandings of process characteristics, and thus assisting the search for possible intervention means to improve process performance. The time dynamics of 150 process parameters acquired from 243 production...

QbD for Generic MR Drug Products

Oct 18, 2011

Yue (Helen) Teng

The Office of Generic Drugs ensures the therapeutic equivalence and quality of generic drug products. This is based principally upon a regulatory paradigm that requires pharmaceutically equivalent drug products containing the same active ingredient, dosage form, and strength (among other things),...

Ab-Initio Study of Glycerol Dehydration Mechanisms with Explicit Solvent Treatment

Oct 18, 2011

Tim Courtney

Glycerol produced as a waste product in biodiesel production has interesting potential as a low-cost biomass-derived feedstock for chemical processing. A process of current academic and commercial interest is the acid-catalyzed dehydration of glycerol to acrolein, a valuable platform chemical. Such...

Membrane Filtration of Lignocellulosic Hydrolyzates: Comparison of Crossflow and Dead-End Microfiltration

Oct 18, 2011

Bhavin Bhayani

Depleting oil reserves have encouraged the development of technologies to harness the natural resources to sustain the energy needs. Renewable lignocellulosic biomasses have been focus of many studies but advances in the purification and recovering of the products from the product medium has been...

Synthesis of Green Diesel Fuel From Fatty Acid Feedstocks Via Electrochemical Hofer-Moest Decarboxylation

Oct 18, 2011

Cody Wagner

Production of biodiesel by esterification or transesterification of long-chain fatty acids is a well known process, but the fuel product has characteristics making it not fully compatible with petroleum diesel engines. A better option is to convert fatty acid molecules to hydrocarbons by removing...

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