Biological Engineering

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From Biochemical Engineering to Synthetic Biology: A Short History of Engineering Impacts on Biotechnology

SBE Webinar

Sep 27, 2012

Harvey Blanch

This webinar will focus on how biochemical engineering developed in response to the need for large-scale production of antibiotics in the 1940s and 50s, even though fermentation provided a route to many industrial organic chemicals prior to their production from petroleum.

Society for Biological Engineering (SBE)

SBE is a global technological community that promotes the integration of engineering with biology and realize its benefits through bioprocessing, biomedical, and biomolecular applications. SBE provides opportunities for interaction of engineers and scientists, develops products and services bring value to the broad biological engineering community, and infuses awareness of biological engineering among all functions and activities of AIChE.

Food, Pharmaceutical & Bioengineering Division (FP & BE)

The FP&BE division coordinates AIChE's activities in the fields of food, pharmaceuticals, and bioengineering.

Forest Bioproducts Division (FBP)

The Forest Bioproducts Division promotes knowledge sharing and networking on topics dealing with products obtained from forest resources and other lignocellulosic materials.

Challenges, Opportunities, and Scientific Aspects of Implementing PAT In Biopharmaceuticals

Oct 19, 2011

Huiquan Wu

As an essential milestone for both the cGMP for the 21 st Century and the recent pharmaceutical quality regulatory initiatives (Q8/Q9/Q10), the 2004 FDA Guidance for Industry “PAT—A Framework for Innovative Pharmaceutical Development, Manufacturing, and Quality Assurance” has proposed a science-...

Inhibitory Effects of Lignocellulosic Degradation Compounds From Hydrolysate On Microbial Oil Production

Oct 19, 2011

Jijiao Zeng

Inhibitory effects of lignocellulosic degradation compounds from hydrolysate on microbial oil production. Jijiao Zeng, Xiaochen Yu, Yubin Zheng, Shulin Chen* Department of Biological Systems Engineering, Washington State University, Pullman, Washington 99164-6120, USA *Corresponding author. Tel: +1...

Use of Single-Use Technologies In Downstream Purification of Mabs - A Case Study

Oct 19, 2011

Venkatesh Natarajan

The employment of single-use technologies in the downstream processing of biologics in general and monoclonal antibodies in particular is gaining significant traction in the industry. Their use eliminates cleaning validation requirements and can potentially offer significant savings in capital...

The Influence of Crystals, Particles and Powders On the Performance of Dry Powder Inhalers

Oct 19, 2011

Jag Shur

This presentation focuses on some key developments in understanding the relationships between the governing properties of DPIs and how these properties can be harnessed to develop designer formulation systems for DPIs.

Model-Based Characterisation of Organic and Aqueous Tablet Film Coating Processes: Parameter Estimation and Risk Management

Oct 19, 2011

Mark A. Pinto

Tablet coating is an important processing step in the pharmaceutical industry in which tablets are coated with an aqueous or organic film coating for both aesthetic and functional reasons. Mathematical models of tablet film coating are important in pharmaceutical development as they aid in design...

Study On Thermo-Bio-Chemical Biorefinery: Fast Pyrolysis of Lignocellulosic Biomass After Hydrolysis Pre-Treatment

Oct 19, 2011

Rene Garrido

Study on Thermo-Bio-Chemical Biorefinery: Fast Pyrolysis of Lignocellulosic Biomass After Hydrolysis Pre-treatment Rene Garrido, Nydia Ruiz-Felix, and Justinus Satrio Chemical Engineering Department, Villanova University, PA 19085 Abstract Biomass-based energy is a renewable source of energy from...

Optimization of a Wild-Type Mesophilic Clostridium Species That Produces Butanol

Oct 19, 2011

Jianzhong He

Optimization of a wild-type mesophilic Clostridium Species that produces butanol Fengxue Xin, Sandhi Eko Bramono, and Jianzhong He* (*Email: jianzhong.he@nus.edu.sg ) The raising energy demands and climate changes have stimulated people to look for sustainable energy. Among the alternatives,...

Mechanistic Models and Computer Software for Quality by Design In Formulation of Modified Release Dosage Forms

Oct 18, 2011

Xiao Yu Wu

Modified release dosage forms (MRDFs) can be designed and manufactured in various shapes and structures using different materials. Depending on the design, formulation and properties of drug and excipients (e.g. polymers), drug release from MRDFs can undergo varying mechanisms. In addition, the...

Cellobiose Hydrolysis Using Acid-Functionalized Nanoparticles

Oct 18, 2011

Leidy Peña

Mineral acids have been used effectively for the pretreatment of cellulosic biomass to improve sugar recovery and promote its conversion to ethanol; however, substantial capital investment is required to enable separation of the acid, and corrosion-resistant materials are necessary. Disposal and...

Effect of Column Temperature On HPLC Separation of Acetic Acid and Levulinic Acid

Oct 18, 2011

Rui Xie

High performance liquid chromatography (HPLC) is a routine method in the analysis of degradation products in the prehydrolysate or the hydrolysis liquor of lignocellulosic biomass. Cation exchange column chromatography with a metal counter ion has been used for the quantitative analysis of...

Co-Utilization of Methane In Steam-Biomass Gasification Using Concentrated Solar Energy

Oct 18, 2011

Aaron W. Palumbo

Presented is a novel gasification application where biomass is steam-gasified and natural gas is steam-reformed simultaneously in a solar reactor. Solar-driven gasification is a proven technology, and can augment the biofuel industry as a domestic fuel source. Gasification performed in an...

Modified AnoporeTM Hybrid Membranes for the Microfiltration of Cellulose Acid Hydrolysis Mixtures

Oct 18, 2011

Yong-Hong Zhao

Three classes of nonfouling substances, poly[poly(ethylene glycol) methyl ether methacrylate] (POEM), poly(sulfobetaine methacrylate) (PSBMA), and perfluoroalkyl tagged poly(ethylene glycol) surfactants (fPEG), were covalently tethered onto the surface of Anopore TM membranes (nominal pore size 0.2...

Heterogeneous Catalysts in the Dehydration of Fructose to HMF

Oct 18, 2011

Sylvia Reiche

Several crucial steps in the upgrading of biomass-derived raw materials involve acid catalyzed reactions, such as the hydrolysis of cellulose or the dehydration of sugars. Although heterogeneous catalysts are desired in large scale industrial processes, their application is limited by several...

Cellulase Inhibition by Pretreatment-Released Biomass Degradation Products

Oct 18, 2011

G. Peter van Walsum

The influence of pretreatment chemistry and the severity of dilute acid pretreatment on the subsequent enzymatic hydrolysis of soluble oligomer-derived and insoluble crystalline cellulose using a commercial enzyme preparation (Novozymes) was investigated. A dilute acid pretreatment was performed on...

Evaluation of Membrane Separations Opportunities within Lignocellulosic Biorefining Processes: Tailoring Membrane Properties

Oct 18, 2011

Jennifer M. Leberknight

Evaluation of Membrane Separations Opportunities within Lignocellulosic Biorefining Processes: Tailoring Membrane Properties Jennifer Leberknight, Amitkumar Gautam, and Todd J. Menkhaus South Dakota School of Mines and Technology Department of Chemical and Biological Engineering 501 East Saint...

Alkaline Deacylation of Corn Stover to Reduce Toxicity of Prehydrolyzates and Improve Enzymatic Hydrolysis

Oct 18, 2011

Urvi D. Kothari

Hydrolysates from dilute acid pretreatment of biomass contain various biomass degradation products which are inhibitory to enzymes and toxic to microorganisms. One of the main inhibitory compounds is acetic acid which is released from the lignin-hemicellulose matrix in the biomass. Acetic acid at...

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