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Biological Engineering

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Society for Biological Engineering (SBE)

SBE is a global technological community that promotes the integration of engineering with biology and realize its benefits through bioprocessing, biomedical, and biomolecular applications. SBE provides opportunities for interaction of engineers and scientists, develops products and services bring value to the broad biological engineering community, and infuses awareness of biological engineering among all functions and activities of AIChE.

Forest Bioproducts Division (FBP)

The Forest Bioproducts Division promotes knowledge sharing and networking on topics dealing with products obtained from forest resources and other lignocellulosic materials.

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Microreactor for Industrial Application: Technical and Economical Benefits

Nov 8, 2010
Sergio Pissavini
A glass based high throughput microreactor technology is presented illustrating the basic design window, technical data and configuration. An overview of some class of reactions performance is provided as compared to batch process. For three typical reaction a comparison between typical plant...

Genomic Approaches to Evolutionary History of Primate Cytochromes c

Nov 8, 2010
Lawrence I. Grossman
Cytochrome c (cyt c) is a highly conserved protein among eukaryotes, mainly owing to its pivotal role in two crucial cellular processes: apoptosis and respiratory chain function. Despite its overall stability, previous studies have reported on the human lineage: (i) a high amino acid evolution rate...

Comprehensive Analysis of Liver Transcriptome Reveals Distinct Disease Signatures

Nov 8, 2010
Yuliang Wang
Major liver diseases such as hepatocellular carcinoma, cirrhosis, and hepatitis affect huge numbers of people. For example, each year, death from liver cancer alone is 662,000 worldwide. Early diagnosis of liver disease is crucial. If identified in time, hepatitis C patients can be treated with...

Design and Construction of a Protein Degradation Switch

Nov 7, 2010
S. Marjan Varedi K.
Targeted protein degradation in eukaryotic cells requires recruitment of the target protein to proteasome which is usually triggered by ubiquitination of the target protein. It has recently been shown that ubiquitination is not necessary and localization to the proteasome is sufficient for...

Modeling Eukaryotic Unfolded Protein Response and Its Role in Cellular Stress

Nov 7, 2010
Anirikh Chakrabarti
Malfunctions in the folding state of critical proteins have been linked with cancer, diabetes and other diseases. Proteins requiring complex post-translational modification are processed in the Endoplasmic Reticulum (ER). Cells monitor protein folding by an inbuilt quality-control system involving...

QbD for Generic Drugs: Modified Release Drug Products

Nov 7, 2010
Andre Raw
The Office of Generic Drugs ensures the therapeutic equivalence and quality of generic drug product pharmaceuticals. This is based principally upon a regulatory paradigm that requires pharmaceutically equivalent drug products containing the same active ingredient, dosage form, and strength (among...

Model-Driven Minimization of the B. Subtilis Genome

Nov 7, 2010
Christopher Henry
Bacillus subtilis is a gram positive, sporulating bacteria often utilized in industry as a producer of high quality enzymes and proteins [1]. The flexible growth conditions, rapid growth rate, and natural competence of B. subtilis make it an ideal candidate for scientific study and industrial use...

QbD for Generic Drugs: A Case Study for Immediate-Release Products

Nov 7, 2010
Zhigang Sun
Quality by design (QbD) is a systematic approach for product and process design and development to ensure predefined product quality. Although the recent ICH guidelines (Q8-Q10) have provided an outline for development of “high quality” pharmaceutical products based on a comprehensive QbD approach...

Novel, Synthetic, Tetracycline-Inducible Transcription Regulators for E. Coli

Nov 7, 2010
Katherine G. Volzing
We are designing, constructing and characterizing novel synthetic gene regulators. These regulators range from individual inducible fusion protein and promoter pairs to complex nonlinear regulatory networks. All of the regulators are designed to be compatible in E. coli and to control gene...

QbD for Generic Drugs: Oral Suspensions

Nov 7, 2010
Umesh Pai
The presentation will be focus on the approach for systematic development of oral suspensions. Suspension is a complex dosage form in which coarse dispersion in which insoluble solid particles (internal phase) is dispersed uniformly throughout the suspending medium (external phase). Strategies for...

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