Biological Engineering

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From Biochemical Engineering to Synthetic Biology: A Short History of Engineering Impacts on Biotechnology

SBE Webinar

Sep 27, 2012

Harvey Blanch

This webinar will focus on how biochemical engineering developed in response to the need for large-scale production of antibiotics in the 1940s and 50s, even though fermentation provided a route to many industrial organic chemicals prior to their production from petroleum.

Society for Biological Engineering (SBE)

SBE is a global technological community that promotes the integration of engineering with biology and realize its benefits through bioprocessing, biomedical, and biomolecular applications. SBE provides opportunities for interaction of engineers and scientists, develops products and services bring value to the broad biological engineering community, and infuses awareness of biological engineering among all functions and activities of AIChE.

Food, Pharmaceutical & Bioengineering Division (FP & BE)

The FP&BE division coordinates AIChE's activities in the fields of food, pharmaceuticals, and bioengineering.

Forest Bioproducts Division (FBP)

The Forest Bioproducts Division promotes knowledge sharing and networking on topics dealing with products obtained from forest resources and other lignocellulosic materials.

A QbD Approach to Selection of Materials for Drug Product Packaging and Medical Devices

Nov 11, 2009

Arthur J. Shaw

This presentation will describe a QbD approach to the selection of materials used to package drug products or to construct medical devices that deliver drug products. Special attention is required for materials that contact drug products due to extractables and leachables (E&L) considerations...

The Use of the Design of Dynamic Experiments Methodology to Quantify the Design Space in QbD Tasks

Nov 11, 2009

Christos Georgakis

The present communication describes a systematic methodology for the quantification of the Design Space characteristics of batch pharmaceutical process. The methodology is applicable to processes which are not known in great detail for a mathematical model to be available. The approach designs a...

Feed-Forward Process Control Strategy for Pharmaceutical Tablet Development

Nov 11, 2009

Koji Muteki

A feed-forward process control strategy which can compensate for the effect of raw material lot-to-lot variability on final tablet attributes in pharmaceutical tablet development is presented. The approach involves building PLS (partial least squares) models that combine raw material attributes and...

Growth Kinetic Study of Chlorella Vulgaris

Nov 11, 2009

Jinsoo Kim

Algae are simple autotrophic organisms that produce complex organic compounds from simple inorganic molecules such as carbon dioxide using energy from light or inorganic chemical reactions. These complex organics include a substantial amount of triacylglycerol which can be readily converted into...

Diurnal Cycling of Triacylglycerides in a Chlorophyte Sp.: Implications for the Production of Algal Biofuels

Nov 11, 2009

Keith Cooksey

There is no doubt that crude oil will be depleted eventually. The concept of global warming is now well accepted. Given these twin constraints, it behooves us to find alternative fuels, especially liquid ones for transportation. Microalgae have the potential to both reduce increases in greenhouse...

Evaluation of Reaction Conversion and Energy Consumption During Biodiesel Production Using a High Shear Mixer Pilot Scale Reactor

Nov 11, 2009

Sipho Ndlela

Biodiesel is a renewable fuel that has the potential to lower vehicle sulfur emissions when used directly or in a blended form, and can be synthesized from fat and oil sources. These sources include refined vegetable oil, crude vegetable oil, waste oil, and animal fat. The two main reaction routes...

Application of Modeling to Scale-up Liquid Mixing Processes

Nov 11, 2009

Venkat R. Koganti

Scale-up of liquid mixing is usually done empirically without considering the several factors like dissolution theory, equipment differences between scales and so on. In this work we present a systematic way to scale-up liquid mixing processes utilizing both Design of Experiment (DoE) approach to...

On the Optimization of the Cooling Profile in Crystallization Using the Design of Dynamic Experiments Approach

Nov 11, 2009

Christos Georgakis

To control the size and shape of crystals during batch crystallization, one must either have an accurate crystal growth and nucleation model or run a series of experiments to find the optimal operating conditions. Since the former is a very intricate and time-consuming task, especially for new...

Optimization of a Pilot Plant for Production of Biodiesel From Jatropha Curcas L. Oil

Nov 11, 2009

Rogelio Sotelo-Boyas

An optimized process on pilot plant scale was carried out for the production of biodiesel from Mexican jatropha curcas L. oil. Initial studies were carried out at lab scale in order to determine the experimental conditions that could lead to a high yield of biodiesel from the alkaline...

Conversion of Inexpensive Oils Into Biodiesel Using ZnO Nanoparticle Catalyst

Nov 11, 2009

Shuli Yan

Biodiesel is a mixture of fatty acid esters which can be produced from vegetable oils or animal fats with methanol. Recently, many researchers focus on using waste or unrefined oils as feedstock to decrease the production cost of biodiesel. A two-step method was reported, which firstly esterified...

Flowchart Methodology Utilizing Validated Process Models as the Foundation for a Quality-by-Design (QbD)-Based Approach for Pharmaceutical Unit Operations: Example Case Studies

Nov 10, 2009

Lisa Graham

A model-based process development methodology is described which uses a Quality by Design (QbD) approach to establish a manufacturing design space. A flowchart methodology is described that illustrates how to rationally step through process development, using fundamental and engineering models and...

Film Coating End-Point Determination for Colored Immediate Release Tablets Using Multivariate Image Analysis

Nov 10, 2009

Salvador Garcia

Quality by design is an exercise that relies on quantitative metrics of the quality of a product. For immediate release (IR) film coated products, the uniformity of the coat is traditionally assessed by visual inspection. It is desired to substitute such assessment with a quantitative one. In this...

Commercial-Scale Energy Crop Production: Establishing Switchgrass in Tennessee

Nov 9, 2009

Timothy Rials

With the advancement of cellulosic ethanol technologies in recent years, more emphasis is being placed on the production of a sustainable supply of biomass for commercial scale facilities. These facilities will require significant supplies of biomass that will, in the southeast, come from private...

Optofluidic SERS Devices for Biomolecular Detection

Nov 9, 2009

Yun Suk Huh

Recently, Surface-enhanced Raman scattering (SERS) has attracted great attention because of its high sensitivity, label-free detection, and low detection limit. Additionally, it provides a specific fingerprint spectrum of multiplex samples with narrow band width. Because of these advantages, a...

Designing Sustainable Options for Bioenergy Crops

Nov 9, 2009

Virginia Dale

Currently, the complexity and scale dependency of land-use decisions and their impacts are not understood, defined, or described with adequate clarity to enable policy makers to develop strategies to ensure a sustainable bioenergy future with acceptable environmental and socioeconomic consequences...

Stability and Reactivity of Enzymatic Papers

Nov 9, 2009

Mohidus Samad Khan

Bioactive papers and paper diagnostics are getting a reality for their low cost, selectivity and application flexibility. Critical is the thermal stability of bioactive papers that need to be shipped and stored. This study quantifies the thermal stability and reactivity of enzymatic bioactive...

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