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Biological Engineering

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Society for Biological Engineering (SBE)

SBE is a global technological community that promotes the integration of engineering with biology and realize its benefits through bioprocessing, biomedical, and biomolecular applications. SBE provides opportunities for interaction of engineers and scientists, develops products and services bring value to the broad biological engineering community, and infuses awareness of biological engineering among all functions and activities of AIChE.

Forest Bioproducts Division (FBP)

The Forest Bioproducts Division promotes knowledge sharing and networking on topics dealing with products obtained from forest resources and other lignocellulosic materials.

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On-Line Monitoring of Roller Compaction Ribbon Density Using NIR Spectroscopy

Nov 9, 2010
Ryan McCann
Solid dosage forms, such as tablets and capsules, have been predominately manufactured through batch processes in pharmaceutical industry for years. The development of continuous manufacturing processes is of high interest to the pharmaceutical industry to reduce the huge costs associated with...

Quantitative Modeling and Analysis of TGF-ß-Induced Erk/MAPK and Smad Signaling

Nov 9, 2010
Seung-Wook Chung
Transforming growth factor ß (TGF-ß), which plays a pivotal role in regulating a wide array of cellular and physiologic processes in both normal and pathological cells, is known to function as a potent tumor suppressor during the early stage of tumorigenesis, primarily by inhibiting cell...

On-Line Blend Monitoring of Pharmaceutical Materials Using Multiple NIR Sensors

Nov 9, 2010
Benoit Igne
In recent years, powder blend monitoring and control systems using process analytical technologies (PAT) have become increasingly popular in the pharmaceutical industry. Among them, spectroscopic techniques allow for real-time evaluation of blend homogeneity and powder behaviors necessary for both...

Real-Time Monitoring of Continuous Processes with Spectroscopic PAT-Tools

Nov 9, 2010
Daniel M. Koller
The aim of Process Analytical Technology (PAT) is to gain deeper insight in pharmaceutical manufacturing processes, replacing empirical approaches by knowledge-based procedures. A detailed understanding of the key parameters of a process and their impact on the product quality allows companies to “...

Raman Spectroscopy Combined with Small and Wide Angle X-Ray Scattering as a Non Destructive Quality Control Tool for Powder Compression Analytics in Pharmaceutical Applications

Nov 9, 2010
Nicolas Heigl
This study evaluates the feasibility of a combined use of small-wide angle X-ray scattering (SWAXS) and Raman spectroscopy as a non-invasive process analytical tool (PAT) for the analysis of pharmaceutical granulation and compression procedures. Placebo formulations containing Lactose monohydrate (...

Stochastic Simulations of the Tetracycline Operon

Nov 9, 2010
Konstantinos Biliouris
The tetracycline (tet) operon is a robust self-regulated system. It is found naturally in bacteria where it confers resistance to antibiotic tetracycline. Because of the performance of the molecular elements (promoters, operators, repressor) of the tetracycline operon, these elements are widely...

Implementation of a Normalization Risk Assessment Tool to Link Design Space Inputs

Nov 9, 2010
Diana S. Hou
Risk analysis and assessment tools are a key component of Quality by Design (QbD) because they facilitate understanding, identifying, and documenting of risks affecting drug product quality attributes. As stated in the ICH Q8 guidelines, the “design space” is where a process generates a product...

Gene Regulation by MAPK Substrate Competition

Nov 9, 2010
Yoosik Kim
Introduction Traditional view of pattern formation in the early Drosophila embryo is essentially one-dimensional: The anterior, posterior, and terminal systems initiate the formation of bands and stripes of gene expression along the AP axis; at the same time, the orthogonal gradient of Dorsal (Dl)...

Optimizing and Controlling High Value Processes Using the Principles of Quality-by-Design (QbD) Advanced Tools Such as Real-Time in-Situ Particle Characterization, in-Situ Mid-Infrared Spectrometry, and Reaction Calorimetry

Nov 9, 2010
Leen Schellekens
Quality by Design (QbD) is a concept applied to gain true process understanding utilizing tools such as Design of Experiment (DoE), Risk Management, and Process Analytical Technology (PAT). Utilization of these principles and tools not only allow the chemist, engineer, or formulator to optimize a...

Renewable Petrochemicals From Biomass by Catalytic Fast Pyrolysis

Nov 9, 2010
George W. Huber
Lignocellulosic biomass has tremendous potential as a feedstock to make renewable fuels and petrochemicals from biomass. The current impediment to the utilization of our biomass resources is that most processes to convert biomass are not currently economical because of long residence times, the...

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