Biological Engineering

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Society for Biological Engineering (SBE)

SBE is a global technological community that promotes the integration of engineering with biology and realize its benefits through bioprocessing, biomedical, and biomolecular applications. SBE provides opportunities for interaction of engineers and scientists, develops products and services bring value to the broad biological engineering community, and infuses awareness of biological engineering among all functions and activities of AIChE.

Forest Bioproducts Division (FBP)

The Forest Bioproducts Division promotes knowledge sharing and networking on topics dealing with products obtained from forest resources and other lignocellulosic materials.

SBE Supplement: Biochemical Engineering - Cell-Free Bioprocessing

November
2013
SBE Special Section
James Swartz
The ability to exploit a cell’s contents and capabilities unimpeded by cell walls opens new opportunities for the field of biochemical engineering. Cell-free biology could become the basis for making products from hydrogen to cancer vaccines and more.

CEP: News Update

November
2013
News Update
Genetically Engineered Yeast Consume Toxic Byproduct; New Device Performs Double Duty; Simulations Shine Light on Future Solar Materials; Closing the Voltage Gap; and more.

Algal Biofuels: The Backstory

March
2011
SBE Special Section
Arjun Gopalratnam
Increasing energy demand and dwindling energy resources have spurred interest in making transportation fuels from renewable sources such as microalgae.

Algal Biofuels: The Process

March
2011
SBE Special Section
Al Darzins, Eric P. Knoshaug
The production of algal biofuels involves algae cultivation, biomass harvesting and dewatering, lipid extraction, and conversion to fuel.

Algal Biofuels: The Research

March
2011
SBE Special Section
Kimberly Ogden, Kuan-Chen Cheng
The individual technical elements of the algae-to-biofuels process have already been demonstrated at the laboratory scale. Ongoing research seeks to refine the technology to enable scaleup to commercial production.

CEP: News Update

July
2013
News Update
Inkjet-Printed Graphene Rolls Out; UV Treatment Improves Membrane Selectivity; Additive Sweetens the Prospects for Organic Electronics; Protective Coating Connects Electronics and Living Tissue; and more.

Biology as a Basis for Biochemical Engineering

July
2013
Back To Basics
Sujata Bhatia
Biochemical engineering demonstrates the versatility of the living cell as a miniature reactor. Living cells can be genetically engineered to produce specific proteins, tuned to manufacture novel enzymes, and optimized to guarantee genetic stability and consistent production of desired products.

CEP: News Update

May
2013
News Update
Artificial Organs Hot Off the Press; Biofuel Byproducts and Concrete Mix It Up; Squid Inspires Material for Medical Implants; Polymer Chains Line Up to Provide High Performance; Ribbons of VO2 and Graphene Enable Ultrafast Batteries; and more.

SBE Update: Drug Delivery and Chemical/Biological Engineering

March
2013
SBE Special Section
June Wispelwey
Although you might not associate drug delivery with chemical engineering, the principles of chemical engineering — such as mass and energy balances, transport phenomena, reaction kinetics, and particle technology — are intimately involved in drug...

Introduction to Drug Delivery Technology

March
2013
SBE Special Section
John T. Santini, Jr.
Drugs can be administered by many routes, yet all emerging drug delivery technologies aim to improve drug efficacy, minimize side effects, and reduce the burden of care for patients and physicians.

Engineering Biodegradable Nanoparticles for Drug and Gene Delivery

March
2013
SBE Special Section
W. Mark Saltzman, Junwei Zhang
Engineered nanoparticles can deliver therapeutic agents to specifically targeted cells and then release those agents in a precisely controlled manner. Improved pharmacokinetic properties, reduced toxicity, and the ability to cross biological barriers are some of the key benefits of this approach.

The Blood-Brain Barrier and Drug Delivery

March
2013
SBE Special Section
William Olbricht
To maintain favorable conditions in the brain, the blood-brain barrier limits mass transfer across brain tissue. However, it also restricts the systemic delivery of compounds to treat neurological disorders. Several treatment alternatives to bypass...

Bioactive Devices: Uniting Form with Function

March
2013
SBE Special Section
Sujata Bhatia
Bioactive implants that combine a medical device with one or more biologic therapeutic agents show promise for the targeted treatment of complex medical conditions. Implantable medical devices, such as stents, grafts, and joint replacements, are...

CEP: Update

March
2013
News Update
Color-Shifting Fibers Take their Lead from Nature; Nanocapsules Target Cancer Cells without Harming Healthy Ones ; Graphene Straightens Out with Some Help from Copper; Silicon Made Easy for Batteries; and more.

Genetically Modified Crops

September
2005
Critical Issues
John Shave
Viewpoint #1 Regulate the Product, Not the Process by Gregory Conko Viewpoint #2 Not All Sugar & Spice

CEP: News Update

February
2013
News Update
Now Available: High-Performance Carbon Nanotube Fibers; Nanowire-Based Solar Cell Achieves Record Performance; Fireflies Share Their Light Tricks with LEDs; Tissue Adhesives Are Inspired by the Prickly Porcupine; New Coating Shields Against Nearly All Liquids; and more.

Piloting Bioreactors for Agitation Scale-Up

February
2008
Reactions and Separations
Gregory T. Benz
This article offers guidance on how to design appropriate experiments to measure scalable data for agitation in both aerobic and anaerobic bioreactors.

CEP: News Update

January
2013
News Update
Global Relationships Take Center Stage at the 2012 Annual Meeting; No Boiling Needed: Nanoparticles Convert Sunlight into Steam; Hydrogen Power Goes Mobile; Carbon Nanotubes Team Up with Graphene; New Process Brings Bendable Electronics Closer to Reality; and more.

AIChE Journal Highlight: An Engineering Roadmap for Biorefining

January
2013
Journal Highlight
In the January AIChE Journal Perspective article, “Engineering Biomass Conversion Processes: A Systems Perspective,” Univ. of Minnesota researchers Prodromos Daoutidis, W. Alex Marvin, Srinivas Rangarajan, and Ana Torres discuss the challenges,...

A MagDot-Nanoconveyor Assay Detects and Isolates Molecular Biomarkers

December
2012
SBE Special Section
Brandon Miller, Jeffrey Chalmers, Jessica Winter, Kalpesh Mahajan, Ratnasingham Sooryakumar, Gang Ruan, Maryam B. Lustberg, M.D., Gregory B. Vieira
The ability to quickly analyze, separate, and manipulate multiple types of biomarkers from small sample volumes is a significant step toward personalized medicine.

Engineered Protein Templates Synthesize Inorganic Nanomaterials

December
2012
SBE Special Section
Sarah Heilshorn, Arunagirinathan Adhimoolam, Alia Schoen, Kelly N. L. Huggins, David T. Schoen
This powerful biomimetic method is a fast, flexible way to produce a wide range of inorganic nanostructures from a single protein scaffold.

SBE Update: The Merging of Bio and Nano

December
2012
SBE Special Section
June Wispelwey
Earlier this year, the Society for Biological Engineering (SBE) organized its Sixth International Conference on Bioengineering and Nanotechnology (ICBN), which focused on bio-nanoscience and bioengineering for translational medicine. The conference...

Engineering Complex Phenotypes in Industrial Strains

November, 2012
This book explains current trends and developments in engineering biocatalysts for the production of bulk chemical and biofuels from renewable biomass. The authors guide readers through the engineering of the complex traits and phenotypes needed for particular biocatalysts and bioprocesses.

ONE-STEP FERMENTATIVE PRODUCTION OF POLYLACTIC ACID

May
2012
SBE Special Section
Min Kyung Kim , Si Jae Park, Sang Yup Lee
The use of PLA has been hindered by its complex and expensive synthesis process. A new technology promises to change this — giving PLA a chance to compete with fossil-based plastics.

CEP: News Update

November
2012
News Update
Magic Act: Electronics Disappear into their Surroundings; New Material Boasts World-Record Efficiency; Brain Cancer Studies Point to a Bio-Based Route to Nylon; Nickel Misbehaves in Li-ion Batteries, Solar Energy Gets Mixed Up

CEP: News Update

October
2012
News Update
New Battery Takes Charge of its Power; Nanomaterial Reversibly Stores Hydrogen; Nanoparticles Sneak Past the Brain’s Armor ; and more

SYNTHETIC SPIDER SILK PROTEINS AND THREADS

May
2012
SBE Special Section
Axel H. Leimer, Lin Römer, Nathalie Mougin, Ute Slotta
E. coli can be genetically engineered to mimic the complex natural process by which a spider makes the proteins that it uses to spin the fibers for its web. With additional processing, fibers with properties similar to those of natural spider silk...

RHEOLOGICAL CHARACTERIZATION OF BIO-BASED MATERIALS

May
2012
SBE Special Section
O.H. Campanella, D. Bhopatkar, P.H.S. Santos
Experimental and analytical tools combined with computational studies can be used to design new bio-based materials tailored for specific applications.

Bio-Based Materials in the New Bio Economy

May
2012
SBE Special Section
Amar Mohanty, Manjusri Misra, Murali M. Reddy
Biological feedstocks are expected to gradually replace some fossil-based raw materials to create eco-friendly products, from car parts and packaging materials to electronic devices and other consumer goods - laying the foundation for a reduced-carbon economy.

CEP: Profile - Engineering Flavors and Bridging Cultures

August
2012
Profile
As the winner of a February 2012 episode of the Food Network’s Cupcake Wars, Winnette McIntosh Ambrose, a National Institute of Health scientist specializing in vision research, demonstrated that inspired chemical engineers can succeed in any realm — when they bring the right ingredients to the mix.

Bio-Based Materials Step into the Operating Room

September
2012
On The Horizon
Sujata K. Bhatia, M.D., P.E.
A new class of implantable medical materials — constructed from naturally derived and renewably sourced polymers — is poised to transform clinical medicine.

CEP: News Update

September
2012
News Update
Slippery Surface Is Too Slick for Bacterial Films; New Materials Put the Brakes on Infection; ITO Flexes Its Muscles; Control Wrinkles with this Simple Method; and more

The Other Bio: Chemicals and Materials

May
2012
SBE Special Section
Miriam Cortes­ Caminero
Just in case you haven’t noticed, a new wave of biotechnology is underway. Over the last three decades, we have seen biological technologies used in therapeutics and agriculture. More recently, we have seen the use of biotechnology for industrial purposes.

Systems Biology and Synthetic Biology

March, 2009
The genomic revolution has opened up systematic investigations and engineering designs for various life forms. Systems biology and synthetic biology are emerging as two complementary approaches, which embody the breakthrough in biology and invite application of engineering principles. Systems...

Applications in Drug Delivery and Tissue Engineering

February
2006
SBE Special Section
Robert Langer, Ali Khademosseini
Nanotechnology is an emerging field that could potentially make a major impact on human health. Nanomaterials promise to revolutionize medicine and are increasingly used in drug delivery or tissue engineering applications.

Using Genomic Tools to Improve the Production of Biologics

November
2009
SBE Special Section
Wei-Shou Hu, Nitya M. Jacob, Wei-Shou Hu, Bernard Liat Wen Loo, and Miranda Yap
Recombinant DNA technology transforms mammalian cells into factories for protein-based therapeutics. New techniques provide chemical engineers with a better understanding of the process as well as the cells themselves.

SBE Special Section - Industrial Biotechnology

October
2005
SBE Special Section
June Wispelwey
Student Chapters Have Arrived! SBE Frontier Tutorial Second Bioengineering and Nanotech Conference Michael Shuler Wins Inaugural James E. Bailey Award Fishing Out Unusual DNA Enzyme is Linked to Neurological Disease

Recombinant Protein Therapeutics from CHO Cells -- 20 Years and Counting

October
2007
SBE Special Section
Wei-Shou Hu, Karthik P. Jayapal, Katie F Wlaschin, Wei-Shou Hu and Miranda G. S. Yap
The CHO cell is at its height of technological prominence thanks to its adaptability to various culture conditions and plasticity in the context of genetic alterations. With further research, the application ofCell Culture Strategies based on...

Engineering a Better Way to Heal Broken Bones

November
2010
SBE Special Section
Matthew B. Murphy
Integrating mesenchymal stem cells and biomaterials shows promise for treating traumatic skeletal injuries via bone tissue engineering.

Producing Fuels and Chemicals from Lignocellulosic Biomass

August
2008
SBE Special Section
Mark Holtzapple, Rocio Sierra, Aaron Smith, Cesar Granda and Mark T. Holtzapple
As oil and natural gas prices rise, lignocellulosic biomass becomes a viable feedstock for the fuel and chemical industries— provided key issues are addressed.

CEP: News Update

August
2012
News Update
Updates Include: The Natural Gas Debate Continues Smart Material Stays Cool in the Heat Firefly-Semiconductor Hybrid Lights Up Ionic Liquid Improves Hydrogen-Producing Catalyst One-Pot Synthesis Yields Zeolites at Bargain Prices High-Carbon Diet...

Developing Cell Therapy Biomanufacturing Processes

November
2010
SBE Special Section
Jon A. Rowley
Establishing scalable technology platforms that allow for varying levels of production throughout the different stages of clinical testing can minimize process development timelines, drug-comparability risks, and — ultimately — costs.

The New Disposable Evolution

July
2009
SBE Special Section
Joanna Ziemlewski
Single-use systems have advanced from a limited product line to several new products for a wider range of unit operations. As these technologies evolve, new size, cost, and regulatory needs continue to fuel industry growth.

Biofiltration - A Primer

April
2001
Environmental Management
Stephen  F. Adler
Use these guidelines to scale up and design biofiltration processes for the control of volatile organic compounds.

Bioprocess Design for a Novel Vaccine

November
2006
SBE Special Section
Barry C. Buckland
The challenges of vaccine development are not limited to identification of suitable antigens, adjuvants and delivery methods, but include regulatory, technical and manufacturing hurdles in translating a vaccine candidate to the clinic.

Metabolic Engineering of Next-Generation Biofuels

August
2008
SBE Special Section
Wendy Higashide, James C. Liao
Engineers are turning to genetic and biological tools and techniques to synthesize higher-chain alcohols that do not suffer from the same limitations as ethanol.

Minimize Scale-Up Risk

March
2010
SBE Special Section
Bertil Stromberg, Thomas Pschorn, J. Brad Cort
Proven commercial-scale equipment already exists for many operations involved in producing biofuels from lignocellulosic feedstocks.

Fulfilling the Promise of Nanomedicine

February
2006
SBE Special Section
Cristina Roman Vas, Rita D'Aquino with Tim Harper
Leveraging nanotechnology in the life science industries has given scientists new tools with which they have the potential to transform the world of medicine.

Industry and SBE News

October
2007
SBE Special Section
Dr. George Georgiou to Receive SBE's James E. Bailey Award; Averting an Epidemic— Novel Device Detects Avian Flu Virus in Less than Half an Hour; Cell-Free Protein Sythesis Comes of Age; Genetically Engineering Microorganisms into Pharmaceutical...

Supplemental Nanobiotechnology Tables

February
2006
SBE Special Section
These tables offer a snapshot of the many companies, research organizations and universities working in nanotechnology, nanoscience, nanobiotechnology and other variations of the term that has been coined to describe a revolutionary approach to...

Ionic Liquid Pretreatment

March
2010
SBE Special Section
Harvey W. Blanch, Bradley M. Holmes, Seema Singh, Blake A. Simmons
Ionic liquids show promise as lignocellulosic biomass solvents. But is this approach a scientific curiosity or a commercially viable biofuel pretreatment technology?

Engineering Organs: Heart and Esophagus

December
2007
SBE Special Section
Buddy D. Ratner
The potential for tissue engineering to transform the practice of medicine is enormous. Chemical engineers will play important roles in this revolution.

Speeding the Design of Bioprocesses

May
2008
SBE Special Section
Sunil Chhatre , Andrew D. Tustian
These experimental and modeling techniques enable the rapid, cost-effective design and scale-up of biopharmaceutical manufacturing in an integrated fashion.

Converting Cellulose to Biofuels

March
2010
SBE Special Section
David Hogsett, Eduardo Ximenes, Youngmi Kim, Nathan S. Mosier, Michael R. Ladisch
Biochemical and thermochemical process technologies being developed to convert wood and other lignocellulosic feedstocks to liquid fuels will drive the transition from corn-based ethanol to advanced biofuels.

Cancer's Newest Deadly Foe

February
2006
SBE Special Section
Suzanne A. Shelley
An array of nanoscale developments are poised to revolutionize cancer diagnosis and drug discovery efforts, and create new ways to target the delivery of potent, often toxic drug therapies, while reducing their dose-limiting side effects.

Bioprinting: Directed Tissue Self-Assembly

December
2007
SBE Special Section
Roger Markwald, Vladimir Kasyanov, Vladimir Mironov
Imagine eliminating patient waiting lists for organ transplants. Bioprinting holds the promise of making this happen, but, must research must be done first.

Keys to Bioreactor Selection

March
2002
Reactions and Separations
John A. Williams
A few basic types of bioreactor designs are used to produce a wide range of products, from antibiotics to foods to fuels. Here's how to pick the best options for your application.

Stem Cell Engineering 101

November
2010
SBE Special Section
Jonathan Monk
Stem cells are poised to transform medical treatments for a host of diseases and malignant conditions. Translating stem cell research into clinical therapies, disease models, and drug-screening platforms will require a combination of sound science...

Avoid the Pitfalls of Bioprocess Development

August
2006
Process Development
Mukesh Doble
This article presents the challenges that an engineer might encounter when designing or scaling up bioprocesses and offers practical solutions, including those cited in literature.

Your Personal Genome for $1,000?

November
2009
SBE Special Section
IBM scientists from four fields — nanofabrication, microelectronics, physics and biology — are collaborating to develop a “DNA transistor” that could make obtaining a personalized genome analysis easier, faster, and cheaper — ultimately as low as $...
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