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SBE Special Section: Biopharmaceuticals - SBE Update: Continuous Progress in Biopharmaceuticals

December
2015
SBE Special Section
Darlene Schuster
The goal of bioprocessing is to optimize natural or artificial biological systems by manipulating prokaryotic and eukaryotic cells and their environment to produce biopharmaceutical products. A bioprocess is divided into upstream and downstream operations. Upstream processing encompasses the steps from preliminary unmodified cell line culture to the mature modified cell culture and harvest; downstream processing includes the separation and purification of the biologics from the mature activated cell culture. These operations have typically been performed as batch processes.

Using Genomic Tools to Improve the Production of Biologics

November
2009
SBE Special Section
Dr. Wei-Shou Hu, Nitya M. Jacob, Wei-Shou Hu, Bernard Liat Wen Loo, and Miranda Yap
Recombinant DNA technology transforms mammalian cells into factories for protein-based therapeutics. New techniques provide chemical engineers with a better understanding of the process as well as the cells themselves.

CEP: Career Corner - Creating Work-Life Harmony

April
2013
Career Corner
Loraine Kasprzak
Work-life balance is a challenge for many of us, but how do we get there from here? First, it helps to adjust our thinking. “It’s not about balance, like weights on a scale,” says Mary T. Scott, a certified professional coach. “It’s more about...

Process Burners 101

August
2013
Back To Basics
Charles Baukal, Erwin Platvoet
Process burners may be classified based on flame shape, emissions, fuel type, and other characteristics. Here’s what you need to know to work effectively with a burner manufacturer when selecting a burner for your application.

3D-Printed Prosthetics Roll Off the Presses

May
2014
On The Horizon
Sujata Bhatia, Shruti Sharma
From implant design to scaffold development and prosthetic construction, 3D printing offers unique solutions for complex problems in the biomedical sciences.

Patents: Crossing the Novelty Threshold

November
2015
Career Catalyst
Henry Heines
Only inventions that are novel qualify for patent protection. Sometimes the novelty of an idea is not readily apparent. Understand where novelty lies so you can identify patentable ideas in your routine engineering work.

Managing Dust Explosion Hazards

August
2009
Safety
Vahid Ebadat, Ph.D.
Companies that handle powders or other particulate solids need to be aware of the potential for fire and explosions, and follow industry best practices, codes and standards to manage the risk.

CEP: Editorial - Moving Beyond the Black Swan Excuse

February
2013
Editorial
Cynthia Mascone
Days after Superstorm Sandy hit the northeastern U.S., I attended the session “Accounting for Beyond Design Basis Events” at the 2012 AIChE Annual Meeting in Pittsburgh, where CCPS Consultant John Murphy gave a talk entitled “Beware the Black Swan...

Characterize Reactive Chemicals with Calorimetry

July
2013
Safety
Dr. Daniel A. Crowl, Jason Keith
In designing and operating chemical manufacturing processes, the reactivity of chemicals must be identified to avoid hazards. Calorimetry experiments combined with analytical methods provide a straightforward technique to identify these reactions...

Special Section: Energy - Lithium-Ion Batteries

October
2013
Special Section
Michelle Bryner
Batteries are being asked to meet daunting performance requirements that could soon be pushing up against the limits of existing battery technologies. Portable electronics, electric vehicles, and grid-scale storage require high energy density and power, low cost, and safety.

CEP: YPOV - Building a Leadership Portfolio

February
2014
YPOV
Janet Werner
When talking with college students at local section meetings, I’m often asked about my responsibilities within AIChE with a simple question: “So, what do you do?” The answer, however, is not so simple. As a leader in the Chicago Local Section, Chicago Young Professionals Committee (YPC), national YPC, and President’s Blue Ribbon Task Force on Local Sections, I could answer this question in several ways.

A Guide to Characterizing Particle Size and Shape

July
2014
Instrumentation
Shrikant Dhodapkar, Remi Trottier
Knowledge of particle properties is essential for understanding how the particles will impact your process. Learn how to identify the relevant properties for a particular application, select the best measurement technique, and analyze the data to extract meaningful information.

CEP: Career Corner - Growing Your Engineering Consulting Practice

August
2014
Career Corner
Loraine Kasprzak
If you want to expand your consulting practice, you must be ready to change how you do things. “As your company matures, you need to start working on the business, rather than in the business. Become the owner, not the doer,” says Stephen Fauer,...

Avoid Fluidization Pitfalls

December
2014
Back To Basics
Raymond Cocco, S. B. Reddy Karri, Ted Knowlton
Fluidized beds are susceptible to such problems as bed slugging, loss of fines, and gas bypassing. This article explains how to avoid these pitfalls.

SBE Special Section: Lignocellulosic Biofuels - SBE Update

March
2015
SBE Special Section
Darlene Schuster
Considering that the price of oil has plummeted to less than half of what it was a year ago, this SBE supplement on biofuels is quite well-timed. What role can and will biofuels play, both today and in the future?

The Future of the Lecture

May
2015
AIChE Journal Highlight
Edward L. Cussler
The lecture is an important and indispensible tool for teaching undergraduate chemical engineering students. The electronics revolution will not dramatically change the basic structure of the lecture, but instead supplement and enhance what is being taught.

CEP: Patent Update - What Constitutes Inducement to Infringe a Patent?

July
2015
Patent Update
Henry Heines
Can you be held liable for patent infringement even if you do not practice the patented invention? Can a company that sells a material to the manufacturer of a patented product be held liable? Can a vendor that supplies a component to a service provider that assembles or uses a patented system be held liable? Can a supplier of raw materials to a production plant that runs a patented process be held liable?

Editorial: What’s On Your Desk?

November
2015
Editorial
Cynthia Mascone
This is an expanded version of the Editorial that appeared in the print version of Chemical Engineering Progress, November 2015. Researchers at Cornell Univ. photographed more than 200 kitchens in Syracuse, NY, to determine whether the food sitting...

Avoid Bulk Solids Segregation Problems

April
2012
Fluids and Solids Handling
Eric Maynard, Eric Maynard
Powder blend consistency can be difficult to maintain during processing. This article provides an overview of common segregation mechanisms, highlights key sampling techniques, and offers practical guidance on preventing and solving segregation...

CEP: Career Corner - Career Success through Networking

October
2013
Career Corner
Loraine Kasprzak
Schmoozing. Glad-handing. Kibitzing. Networking — the art of cultivating productive relationships — often gets a bad rap. Yet without some form of networking, it may be difficult for you to get a promotion, make a career change, or land a six-figure...

Follow this Process Development Path

December
2013
Reactions and Separations
Paul Szabo
Bench-scale engineering (BSE) and the interdisciplinary no-transfer team (INTT) are valuable complements to the scale-down-before-scale-up method of process development.

CEP: Editorial - Get Smart about Electricity

August
2014
Editorial
Cynthia Mascone
According to the Edison Foundation, nearly 40% of U.S. households, about 46 million residences, are outfitted with a smart meter for monitoring and managing electricity use. Some of these meters operate under direct load control (DLC), which allows the utility to intermittently interrupt service to connected appliances — such as electric heaters, central air conditioning systems, water heaters, hot tubs, and clothes dryer heating elements — during periods of peak electricity demand. In return for their willingness to accept these short (typically no more than a few hours) power interruptions, customers receive a payment or a credit on their electric bill. Smart metering is a form of demand-side management, and is an important part of the evolving smart grid.

Select the Best Model for Two-Phase Relief Sizing

May
2001
Safety
Ronald Darby, Ron Darby, Paul R. Meiller, & Jarad R. Stockton
A variety of methods exist for sizing valves, but not all give the best predictions for certain conditions. RonDarby-PaulR.Meiller-JaradR.Stockton-

Automate Your Batch Process — Part 1

August
2015
Instrumentation
Cecil Smith
It is important to understand the process to automate it effectively. Learn about the automation requirements of cyclical, multigrade, and flexible batch processes, as well as the status of this developing field.

SBE Special Section: Biopharmaceuticals - Continuous Processing in Downstream Operations

December
2015
SBE Special Section
Todd Przybycien, Professor Nigel Titchener-Hooker
The transition from batch to continuous downstream processing of biologics has been gradual, with some processes integrating continuous and batch operations. A fully continuous, commercial-scale downstream process has yet to be implemented. Find out why, as well as the current status of the technology.

CEP: Editorial - Harnessing Our Abilities

October
2014
Editorial
Cynthia Mascone
We all have limits to our abilities. Some of us stumble over our words and lose our train of thought when speaking to a group; others can’t string together three coherent sentences. Some of us get so bogged down in minutiae that we lose sight of the big picture; others are so busy dreaming up the next project that we neglect important details and miss deadlines. This thinking extends to physical characteristics. Some of us are so short that we can’t reach the second shelf in the cabinet; others are so tall that we can’t fit into the backseat of a car.

Working with Tight Oil

April
2015
Back To Basics
Timothy Olsen
Crude oil derived from shale plays is less expensive and more readily available than traditional crudes, but it poses unique challenges to refiners.

Synthetic Biology: Putting Together the Pieces

July
2015
On The Horizon
Michelle Bryner
Synthetic biology represents a new way of building biological systems via engineering tools and principles. Genetic components and pathways will be created to reprogram organisms, endowing them with novel functions for a wide range of applications.

Use TRIZ in Reverse to Analyze Failures

May
2005
Career Catalyst
Jack Hipple
Asking “how could I make this fail?” can help you to identify potential problems that you might not otherwise have considered.

Bringing a Star to Earth

April
2009
Special Section
Jan Berry, Bond Calloway
An international R&D effort to build a fusion reactor and demonstrate the feasibility of fusion power is underway.

Handle Bulk Solids Safely and Effectively

September
2009
Fluids and Solids Handling
Eric Maynard, Greg Mehos and Eric Maynard
Follow these guidelines for proper design of bins, hoppers, and feeders to avoid operational and safety problems.

Mitigate Air Pollution with Catalytic Technology

June
2014
Environmental Management
Kristine Baranski, Bailey Underwood
Catalytic oxidation and catalytic reduction control emissions by chemically transforming pollutants. Learn what equipment is available and how it works to treat exhaust streams from stationary sources.

Designing Pneumatic Conveying Systems

May
2006
Fluids and Solids Handling
Eric Maynard
Use this 9-step methodology to design and operate a reliable and cost-effective system to efficiently transport materials.

Cool Down with Liquid Nitrogen

September
2015
Heat Transfer
Oscar Beteta, Svetlana Ivanova
Many low-temperature processes leverage nitrogen’s cooling and freezing capabilities. Find out what methods are used in what applications and why.

Career Corner: Ace Your Skype or Phone Interview

December
2015
Career Corner
Loraine Kasprzak
If you are interviewing for a new job, there is a good chance that at least your first interview will be conducted by phone or using online videoconferencing software, such as Skype. These methods are both convenient and cost-effective for the...

Energy Research: Following the Money

July
2010
Special Section
Bond Calloway
Surveys of the energy-related papers presented at AIChE’s annual meetings shed light on the funding pathways for energy research by chemical engineers.

SBE Update: The Merging of Bio and Nano

December
2012
SBE Special Section
June Wispelwey
Earlier this year, the Society for Biological Engineering (SBE) organized its Sixth International Conference on Bioengineering and Nanotechnology (ICBN), which focused on bio-nanoscience and bioengineering for translational medicine. The conference...

The Blood-Brain Barrier and Drug Delivery

March
2013
SBE Special Section
William Olbricht
To maintain favorable conditions in the brain, the blood-brain barrier limits mass transfer across brain tissue. However, it also restricts the systemic delivery of compounds to treat neurological disorders. Several treatment alternatives to bypass...

Selecting the Optimal Cooling Tower Fill

August
2013
Heat Transfer
Paul Puckorius
The most important action of an evaporative cooling tower occurs on the heat-transfer surface — called fill — inside the tower. Follow these guidelines to choose the appropriate fill for your application.

Spray Nozzles 101: Spray Nozzle Selection

August
2014
Back To Basics
Charles Lipp
Understand the two most common spray nozzle designs, as well as their basic characteristics, in order to choose the best nozzle for your application.

Is Your Dust Collection System An Explosion Hazard?

October
2003
Safety
Vahid Ebadat, Ph.D.
The prevalence of dust explosions in dust collection units may be due to the fact that the hazards posed by the powders handled are not fully understood or that explosion preventive and protective control measures are insufficient or absent. This...

CEP: Career Corner - Becoming a Leader

August
2013
Career Corner
Loraine Kasprzak
What do Sheri McCoy, CEO of Avon Products, the late Robert Goizueta, former Chairman and Chief Executive of Coca-Cola, and Andrew Grove, former Chairman and CEO of Intel, have in common? They all started their careers as chemical engineers and later...

How Much Is Another Measurement Worth?

January
2014
Instrumentation
Douglas C. White
New measurements are valuable only if they increase the economic value of the plant. Evaluate a measurement investment by quantifying the expected improved financial performance.

Troubleshoot Acid-Gas Removal Systems

July
2014
Reactions and Separations
Chris Bickham, Eric Teletzke
The removal of acid gases is a key step in natural gas treatment. Closed-loop amine systems are a popular option, but they can suffer from inefficiencies. Use these troubleshooting tools to pinpoint the cause of operational issues.

Switzerland: The Success of Its Chemicals and Pharmaceuticals Industries

December
2013
Global Outlook
Konrad Hungerbühler, Stavros Papadokonstantakis, Marcel Sennhauser
The strong international presence of Switzerland’s chemicals industries — characterized by a major export market and substantial investment in its companies abroad — has helped to make the Swiss chemicals and pharmaceuticals industries among the world’s most successful.

CEP: Commentary - Educating Students to Become Engineers

June
2014
Commentary
R Russell Rhinehart
The article “How Well Are We Preparing ChE Students for Industry?” in the Update section of the April issue of CEP (pp. 4–5, 14–15) meshed with my career-long concern about engineering education. I graduated in 1968, with pride in my skills, from “a strong program” that “was about to break into the top ten,” as we were told. It was a good program in many ways, but after two years in industry, I came to realize the misdirected perspectives I had acquired as a student. After 13 years in industry and 28 in academia, I have concluded that neither the academic perception of excellence nor the tasks students are required to complete align with the perceptions and tasks that lead to success in industry.

CEP: Editorial - It’s All About the Culture

December
2014
Editorial
Cynthia Mascone
December 3 marks the 30th anniversary of the worst chemical accident in history — the catastrophic release of methyl isocyanate (MIC) from a pesticide plant in Bhopal, India, in 1984 that resulted in thousands of deaths and hundreds of thousands of injuries. Two articles and the Process Safety Beacon in this issue review some of the lessons learned from that tragic incident.

Employment of Chemical Engineers

January
2002
Special Section
Freeman Self , Freeman Self
An analysis of past employment data can help identify future trends in chemical engineering. FreemanSelf-EdEkholm-

Chemical Looping Rises to the Challenge

May
2015
On The Horizon
Liang-Shih Fan, Liang Zeng, Siwei Luo
By separating a reaction into several subreactions, chemical looping minimizes exergy loss, facilitates product separation, and provides flexibility in process design.

CEP: Process Automation Corner – The U.S. Chemicals Industry in Perspective

June
2015
Process Automation Corner
Terrence McMahon
If the U.S. economy were a professional sports league, the chemicals industry would be a franchise player. A healthy economy needs a core of financially strong, internationally competitive industries making products that can be sold in any geographic market. These industries provide highly compensated employment opportunities, which in turn creates flourishing communities and intellectual capital potential. Improved production processes and higher-quality products do not develop in a vacuum, but rather in the context of solving day-to-day production problems. Without domestic manufacturing, these opportunities are lost. Franchise industries are also export machines. This last quality is vital to a healthy economy — chronic trade deficits are a harbinger of decline.

Patent Update: Process Claims: Know Your Infringer

September
2015
Patent Update
Henry Heines
Process patents are an important class of patents, as many inventions are best-defined, or most clearly patentable, as processes. In many cases, a well-crafted process claim can keep the most threatening competitors at bay and be highly lucrative...

Profile: Emily Leproust: Revolutionizing DNA Syntheses

December
2015
Profile
Emily Leproust, CEO and co-founder of Twist Bioscience, is reinventing the wheel when it comes to DNA synthesis. “I have one goal with respect to DNA synthesis — that’s to make cloning obsolete,” she says. Synthetic DNA can be used to modify the...

Consider Recycled Water for Your Cooling Tower Makeup

February
2013
Heat Transfer
Paul Puckorius
Many types of “used” water may be appropriate as cooling tower makeup. Here’s how to determine which waters are suitable and cost-effective for the equipment in your cooling system.

Sizing Pressure-Relief Devices

October
2013
Back To Basics
Dr. Daniel A. Crowl, Scott A. Tipler
Although relief devices may never be activated, they must be designed and sized to function correctly every time they are necessary. This article provides an introduction to sizing pressure-relief devices for liquid and vapor service.

CEP: Editorial - Whatever You Do, Don’t Look Down

March
2014
Editorial
Cynthia Mascone
You’ve spent hours writing your paper, preparing the slides for your presentation, and practicing your talk. You’ve endured the humiliation of the airport security inspection, the frustration of the weather-related flight delay, the discomfort of the cramped airplane seats, and the disruption of your circadian rhythm after crossing several time zones. You arrive at the meeting room early, check your slides on the session chair’s laptop, get comfortable with the remote, and test the mic. You are excited to be part of this group of experts, and are looking forward to sharing your thoughts and engaging in a lively dialogue.

CEP: YPOV - Anything Can Change, But Not Everything Must

September
2014
YPOV
Alex Ruddick
Good morning! Or should I say good evening? The sun is just setting as I write this in Mangalore, India, where the time leads the U.S. by half a day. By the time this article is printed, India Standard Time will join the growing list of time zones...

Apply Can’t Rather than Don’t to Your Process

December
2014
Safety
William Levinson
Many safety systems rely on human intervention to prevent incidents. A different approach is to make it impossible for a catastrophic accident to occur. Learn how to implement the Can’t Rather than Don’t principle.

Recognize Hazards to Recognize Change

April
2015
Safety
Donald Lorenzo, Mark Suyama, Della Wong
Improve your management of change (MOC) system by training workers to recognize hazards as indicators of change.

Do Your Due Diligence

July
2015
Career Catalyst
Herbert Cooper
Use this guidance to conduct comprehensive due diligence assessments and help ensure your acquisitions — of equipment, technologies, facilities, or companies — are operationally and technologically successful.

CEP: Spotlight on Safety - Sensing Safety

August
2015
Spotlight on Safety
Louisa Nara
Most of us are fortunate enough to have five working senses — sight, hearing, touch, smell, and taste. We use these personal, internal feedback loops to perceive and understand our surroundings, which makes our senses some of our most valuable and essential safety equipment. Before the advent of optical, vibrational, and auditory sensors, the chemical process industries (CPI) depended on sensory perception to identify operational upsets or changes. Although sensing equipment is now ubiquitous in CPI facilities, we must also use our senses to collect critical safety data, rather than blindly relying on equipment to signal unsafe conditions.

CEP Editorial: Help Grow AIChE’s Apprentice Program

April
2013
Editorial
Cynthia Mascone
If you are a young professional under the age of 35 and are willing to assume a leadership role in AIChE (on a project of your choice), the AIChE Foundation, through its Young Professionals Apprentice program ( CEP, Sept. 2012, p. 72), will...

The Growth of a Chemicals Industry in Russia

October
2014
Global Outlook
German Dyakonov, Nelly Lyzhina, Nadir Ziyatdinov
Russia’s chemicals industry has experienced ups and downs since its formation. Although the country was hit hard by the Great Recession, it appears to have bounced back and is now investing in modernizing highly outdated equipment and processes.

SBE Special Section: Lignocellulosic Biofuels - Full 32-Page Supplement

March
2015
SBE Special Section
Tristan R. Brown, Robert Brown, Sergio C. Capareda, Bruce E. Dale, David Edwards, Vonnie Estes, Cesar Granda, Mark Holtzapple, Sagar Lonkar, Darlene Schuster, Charles Wyman
SBE Update; The Need for Biofuels; Producing Biofuels via the Thermochemical Platform; Producing Biofuels via the Sugar Platform; Producing Biofuels via the Carboxylate Platform; Scaling Up Bioenergy Technologies; Commercial-Scale Production of Lignocellulosic Biofuels
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