Pharmaceutical Engineering & Drug Delivery

CEP: AIChE Journal Highlight - Layer-by-Layer Approach Enables Customizable Medication Therapy

April
2015
Journal Highlight
In the April AIChE Journal Perspective article, “Layer-by-Layer Approaches to Staging Medicine from Surfaces,” Paula T. Hammond of the Massachusetts Institute of Technology describes her research on a method that creates layers of thin films stacked on top of one another. Each layer contains a different therapeutic, which is incorporated into the thin film via one of several mechanisms (e.g., charge, hydrogen bonding, or other complementary interaction). This technique is useful for drug therapy in applications such as bone regeneration.

Engineering Global Biological Solutions

Conference Presentation
AIChE Annual Meeting
Monday, November 17, 2014 - 11:15am-12:15pm
The past decades have seen biopharmaceuticals begin to dominate the drug development pathway and already we can see potent biologics bringing...

On the Modeling of Oral Drug Delivery

Conference Presentation
AIChE Annual Meeting
Thursday, November 1, 2012 - 12:30pm-1:00pm
On the Modeling of Oral Drug Delivery Naresh Pavurala, Luke E.K Achenie Department of Chemical Engineering, Virginia Polytechnic Institute and State...

Automation and Control of Drug-On-Demand Technology

Conference Presentation
AIChE Annual Meeting
Wednesday, October 31, 2012 - 5:15pm-5:45pm
Stimulated by initiatives such as PAT and QbD, the pharmaceutical industry has been focusing on the development of innovative, efficient...

A QbD Approach to the Process Development of Tofacitinib

Conference Presentation
AIChE Annual Meeting
Wednesday, October 31, 2012 - 1:15pm-1:30pm
Tofacitinib citrate (CP-690,550-10) is currently being evaluated for the treatment of rheumatoid arthritis, psoriasis and other diseases. An NDA has...

Optimal Design of Transient Microreactor Experiments

Conference Presentation
AIChE Annual Meeting
Tuesday, October 30, 2012 - 12:30pm-1:00pm
Development of synthetic routes for active pharmaceutical ingredient (API) synthesis is increasingly performed using microreactors, because their use...

A Novel QbD Tool for Statistical Data Analysis

Conference Presentation
AIChE Annual Meeting
Tuesday, October 30, 2012 - 10:15am-10:30am
One of cornerstones of Quality by Design (QbD) is Design of Experiments (DoE). However, in addition to DoE, ICH Q8 (R2) recommends an enhanced...

Modelling of a Filter Drying Process

Conference Presentation
AIChE Annual Meeting
Monday, October 29, 2012 - 5:15pm-5:45pm
Filter drying, also referred to as vacuum contact drying, is a process widely used in the pharmaceutical industry to remove water or organic solvents...

QbD In Dry Powder Inhaler Development

Conference Presentation
AIChE Annual Meeting
Wednesday, October 19, 2011 - 8:00pm
Summary Developing products comprising un-bound fine cohesive powders throws up significant challenges. Dry powder inhalers present a prime example...

Scaling up Strategy for Continuous Powder Mixing Process

Conference Presentation
AIChE Annual Meeting
Wednesday, October 19, 2011 - 8:00pm
Scaling up strategy for continuous powder mixing process Yijie Gao, Fernando Muzzio and Marianthi G. Ierapetritou Dept. of Chemical and Biochemical...

Managing Uncertainty In Design Space

Conference Presentation
AIChE Annual Meeting
Wednesday, October 19, 2011 - 8:00pm
Design of experiments, followed by numeric and graphical optimization, is frequently used by engineers to optimize a process, and to define a design...
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