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Pharmaceutical Engineering & Drug Delivery

Introduction to Drug Delivery Technology

March
2013
SBE Special Section
John T. Santini, Jr.
Drugs can be administered by many routes, yet all emerging drug delivery technologies aim to improve drug efficacy, minimize side effects, and reduce the burden of care for patients and physicians.

Engineering Biodegradable Nanoparticles for Drug and Gene Delivery

March
2013
SBE Special Section
Junwei Zhang, W. Mark Saltzman
Engineered nanoparticles can deliver therapeutic agents to specifically targeted cells and then release those agents in a precisely controlled manner. Improved pharmacokinetic properties, reduced toxicity, and the ability to cross biological barriers are some of the key benefits of this approach.

The Blood-Brain Barrier and Drug Delivery

March
2013
SBE Special Section
William Olbricht
To maintain favorable conditions in the brain, the blood-brain barrier limits mass transfer across brain tissue. However, it also restricts the systemic delivery of compounds to treat neurological disorders. Several treatment alternatives to bypass...

Bioactive Devices: Uniting Form with Function

March
2013
SBE Special Section
Sujata Bhatia
Bioactive implants that combine a medical device with one or more biologic therapeutic agents show promise for the targeted treatment of complex medical conditions. Implantable medical devices, such as stents, grafts, and joint replacements, are...

SBE Update: Drug Delivery and Chemical/Biological Engineering

March
2013
SBE Special Section
June Wispelwey
Although you might not associate drug delivery with chemical engineering, the principles of chemical engineering — such as mass and energy balances, transport phenomena, reaction kinetics, and particle technology — are intimately involved in drug...

Building a Better Biofuel Production Platform

Oct 17, 2011
Stevan Albers
Building a Better Biofuel Production Platform: Engineering metabolic control techniques to control the photosynthetic cyanobacterium Synechocystis sp. PCC 6803 Stevan C. Albers 1 , Christie A.M. Peebles 1,2 1 Cell and Molecular Biology Graduate Program, 2 Department of Chemical and Biological...

Metabolic Flux Analysis of Escherichia Coli MG1655 Under Octanoic Acid Stress

Oct 17, 2011
Yanfen Fu
Metabolic engineering has evolved to the point of fulfilling the dream of having our industrial chemicals produced renewably. Carboxylic acids (e.g., short chain fatty acids (SCFAs) such as octanoic acid (C8)) are one such chemical intermediate that can be produced with Escherichia coli engineered...

Scaling up Strategy for Continuous Powder Mixing Process

Oct 19, 2011
Yijie Gao
Scaling up strategy for continuous powder mixing process Yijie Gao, Fernando Muzzio and Marianthi G. Ierapetritou Dept. of Chemical and Biochemical Engineering, Rutgers University, Piscataway, NJ 08854 Continuous powder mixing has attracted a lot of interest among pharmaceutical industry. Based on...

Managing Uncertainty In Design Space

Oct 19, 2011
Patrick J. Whitcomb
Design of experiments, followed by numeric and graphical optimization, is frequently used by engineers to optimize a process, and to define a design space or operating window. It is critical to understand the boundaries of this operating window – if you choose a specific set of operating conditions...

Scale and Bioreactor Design Translation for Rocking Bag Bioreactors

Oct 19, 2011
John Bowers
Scale and Bioreactor Design Translation for Rocking Bag Bioreactors. The translations of scale and bioreactor designs for disposable rocking bag bioreactors are currently performed intuitively or with trial an error approaches. Conditions are typically based on manufacturer recommendations or...

Use of Single-Use Technologies In Downstream Purification of Mabs - A Case Study

Oct 19, 2011
Venkatesh Natarajan
The employment of single-use technologies in the downstream processing of biologics in general and monoclonal antibodies in particular is gaining significant traction in the industry. Their use eliminates cleaning validation requirements and can potentially offer significant savings in capital...

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