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Molecular, Cellular, & Tissue Engineering

Singapore: An Emerging Leader in Biomedical Sciences

October
2007
SBE Special Section
Miranda G. S. Yap, Niki S. C. Wong
With a heavy investment in biomedical research— particularly the $330 million to build Biopolis in 2003— Singapore is seeing the fruits of its labor blossom.

Recombinant Protein Therapeutics from CHO Cells -- 20 Years and Counting

October
2007
SBE Special Section
Karthik P. Jayapal, Katie F Wlaschin, Wei-Shou Hu and Miranda G. S. Yap , Wei shou Hu
The CHO cell is at its height of technological prominence thanks to its adaptability to various culture conditions and plasticity in the context of genetic alterations. With further research, the application ofCell Culture Strategies based on...

Deciphering the Mechanisms of Therapeutic Protein Production

October
2007
SBE Special Section
Christoph L. Bausch, Daniel W. Allison, Kevin J. Kayser, Matthew V. Caple, Trissa Borgschulte
Demand for therapeutic recombinant proteins will eventually exceed current production capabilities. This is a major driver in further understanding Chinese Hamster Ovary (CHO) cell biology, which is the cell line of choice for producing these...

Using Genomic Tools to Improve the Production of Biologics

November
2009
SBE Special Section
Nitya M. Jacob, Wei-Shou Hu, Bernard Liat Wen Loo, and Miranda Yap , Wei shou Hu
Recombinant DNA technology transforms mammalian cells into factories for protein-based therapeutics. New techniques provide chemical engineers with a better understanding of the process as well as the cells themselves.

Your Personal Genome for $1,000?

November
2009
SBE Special Section
IBM scientists from four fields — nanofabrication, microelectronics, physics and biology — are collaborating to develop a “DNA transistor” that could make obtaining a personalized genome analysis easier, faster, and cheaper — ultimately as low as $...

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