Molecular, Cellular, & Tissue Engineering

Xylitol is a five-carbon sugar alcohol and has been used as a sugar substitute in the food industry because of its low caloric and anti-carcinogenic characteristics. In addition, xylitol is a building block for a variety of commodity chemicals. Biological routes for producing xylitol from...

There has been considerable emphasis in the recent years on applying systems approaches to decipher and reconstruct cellular networks using high-throughput data. To avoid over-fitting the data and to ensure that the resulting model has good predictive power, cross-validation is often used in data-...

Lung diseases include some of the most widespread and deadly conditions known to affect people in the US today. One of the main challenges in treating lung disease is the difficulty of diagnosis. Clinical diagnosis remains largely dependent upon symptomatic-based diagnoses; many cases can be either...

Mathematical modeling of complex signal transduction and gene expression programs is an emerging tool for understanding disease mechanisms. However, conventional wisdom suggests that the data requirement to identify and validate complex mechanistic models is too large. Typically, it is not possible...

Transforming growth factor ß (TGF-ß), which plays a pivotal role in regulating a wide array of cellular and physiologic processes in both normal and pathological cells, is known to function as a potent tumor suppressor during the early stage of tumorigenesis, primarily by inhibiting cell...

Understanding the molecular basis of differentiation programs is one of the grand unmet challenges facing modern cell-biology. In this study, we integrated computational and experimental network analysis to unravel the response of HL-60 human myeloblastic leukemia cells to Retinoic Acid (RA)...

The objective of the present study is to integrate the information on intracellular signaling network structures with large-scale gene expression data sets to predict functional changes in the cellular pathways that are operational under those conditions. Conventional approaches do not consider the...

Tuberculosis (TB) is a common and deadly infectious disease caused by a highly successful bacterium, Mycobacterium tuberculosis (Mtb). Multiple host immune factors control the formation of a self-organizing aggregate of immune cells termed a granuloma in the lungs after inhalation of Mtb. One such...

Cancer is caused by multiple gene mutations that each contribute to the transformation of normal cells. There is more to be learned, however, about the sequence of this transformation and how the genes involved are cooperating to produce cancerous cells. Drastic changes in the expression of a...