Molecular, Cellular, & Tissue Engineering

Multiscale Modeling and Analysis of TRPV1 Regulation in Sensory Neurons

Nov 8, 2010
Jeffrey D. Varner
TRPV1 (transient receptor potential vanilloid subtype 1) receptors play a central role in nociception and inflammatory pain. Interestingly, both agonists and antagonists of TRPV1 have been tested therapeutically, suggesting that the regulation of TRPV1 activity is a complex balance between pro- and...

 A Microrna Based Synthetic Network as Stable Expression Unit in Mammalian Cells

Nov 7, 2010
Leonidas Bleris
The utility and scalability of complex synthetic gene networks is hampered by fluctuations in stoichiometry between different gene products in individual cells. A critical contribution to the fluctuations arises from variation in the basic transcription efficiency of a gene product that in turn is...

Molecular Elucidation and Engineering of Stem Cell Microenvironments

SBE Webinar
Jan 21, 2010

Stem cells are defined by their capacities for self-renewal and differentiation into one or more cell lineages, and these processes are regulated by signals from the stem cell microenvironment, or niche, in various tissues throughout organismal de

Engineering Organs: Heart and Esophagus

December
2007
SBE Special Section
Buddy D. Ratner
The potential for tissue engineering to transform the practice of medicine is enormous. Chemical engineers will play important roles in this revolution.

Bioprinting: Directed Tissue Self-Assembly

December
2007
SBE Special Section
Roger Markwald, Vladimir Kasyanov, Vladimir Mironov
Imagine eliminating patient waiting lists for organ transplants. Bioprinting holds the promise of making this happen, but, must research must be done first.

Consider Using Fluoropolymers in Biological Applications

December
2004
Materials
Lauri Jenkins, Sharon Libert, Victor Lusvardi
Even with the use of costly corrosion-resistant alloys, metal contamination continues to occur in the biologics industry, thus reducing product yield and activity. Fluoropolymers are emerging as a viable solution to this problem.

Industry and SBE News

October
2007
SBE Special Section
Dr. George Georgiou to Receive SBE's James E. Bailey Award; Averting an Epidemic— Novel Device Detects Avian Flu Virus in Less than Half an Hour; Cell-Free Protein Sythesis Comes of Age; Genetically Engineering Microorganisms into Pharmaceutical...

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