Molecular, Cellular, & Tissue Engineering

Experimental and Mathematical Approaches to Multi-Scale Analysis of Tumor Necrosis Factor-Regulated Immune Response to Tuberculosis

Nov 8, 2010

Mohammad Fallahi-Sichani

Tuberculosis (TB) is a common and deadly infectious disease caused by a highly successful bacterium, Mycobacterium tuberculosis (Mtb). Multiple host immune factors control the formation of a self-organizing aggregate of immune cells termed a granuloma in the lungs after inhalation of Mtb. One such...

Using Inducible Gene Expression to Characterize Oncogene Cooperation in a Murine Pre-B Cell Line

Nov 8, 2010

Jonathan Vroom

Cancer is caused by multiple gene mutations that each contribute to the transformation of normal cells. There is more to be learned, however, about the sequence of this transformation and how the genes involved are cooperating to produce cancerous cells. Drastic changes in the expression of a...

Omics Analysis of Agrobacterium Sp. Uncovers Regulatory Factors for Polysaccharide Biosynthesis

Nov 8, 2010

Anne Ruffing

Microbial polysaccharides are primary cellular components and integral to many cellular functions including cell adhesion, biofilm formation, pathogenesis, and protection from the environment. Despite their ubiquity and functional importance, the regulation of polysaccharide biosynthesis remains...

Multiscale Modeling and Analysis of TRPV1 Regulation in Sensory Neurons

Nov 8, 2010

Jeffrey D. Varner

TRPV1 (transient receptor potential vanilloid subtype 1) receptors play a central role in nociception and inflammatory pain. Interestingly, both agonists and antagonists of TRPV1 have been tested therapeutically, suggesting that the regulation of TRPV1 activity is a complex balance between pro- and...

Using Synthetic Biology to Engineer Syntrophic Microbial Communities for Bioprocess Applications

Nov 7, 2010

Ross P. Carlson

A combination of synthetic biology and in silico network analysis was used to construct artificial microbial consortia comprised of engineered Escherichia coli strains. The design was based on biomimicry of key ecological roles found in stable, naturally occurring microbial consortia. In silico...

A Microrna Based Synthetic Network as Stable Expression Unit in Mammalian Cells

Nov 7, 2010

Leonidas Bleris

The utility and scalability of complex synthetic gene networks is hampered by fluctuations in stoichiometry between different gene products in individual cells. A critical contribution to the fluctuations arises from variation in the basic transcription efficiency of a gene product that in turn is...

Breaking the Cell Wall Barrier for Difficult-to-Express Natural and Supernatural Products

SBE Webinar

May 27, 2010

James Swartz

Modern recombinant DNA expression technologies, by definition, challenge cells to engage in unnatural acts; specifically, the production of new types and large quantities of proteins for which the cells have not evolved.

Molecular Bioprocessing as a New Paradigm for Drug Discovery

SBE Webinar

Mar 2, 2010

Jonathan Dordick

The drug discovery process is expensive and often inefficient. With the emergence of genomic and proteomic information, the growth of critical molecular targets is rapid.

Molecular Elucidation and Engineering of Stem Cell Microenvironments

SBE Webinar

Jan 21, 2010

Stem cells are defined by their capacities for self-renewal and differentiation into one or more cell lineages, and these processes are regulated by signals from the stem cell microenvironment, or niche, in various tissues throughout organismal de

A Bottom Up Approach to Systems Biotechnology – Lessons Learned from Bacterial Signal Transduction

SBE Webinar

Dec 8, 2009

William E. Bentley

Bacterial quorum sensing offers an interesting viewpoint from which to study and control cell phenotype.

Deciphering the Mechanisms of Therapeutic Protein Production

October

2007

SBE Special Section

Christoph L. Bausch, Daniel W. Allison, Kevin J. Kayser, Matthew V. Caple, Trissa Borgschulte

Demand for therapeutic recombinant proteins will eventually exceed current production capabilities. This is a major driver in further understanding Chinese Hamster Ovary (CHO) cell biology, which is the cell line of choice for producing these...

Using Genomic Tools to Improve the Production of Biologics

November

2009

SBE Special Section

Nitya M. Jacob, Wei-Shou Hu, Bernard Liat Wen Loo, and Miranda Yap , Wei shou Hu

Recombinant DNA technology transforms mammalian cells into factories for protein-based therapeutics. New techniques provide chemical engineers with a better understanding of the process as well as the cells themselves.

Your Personal Genome for $1,000?

November

2009

SBE Special Section

IBM scientists from four fields — nanofabrication, microelectronics, physics and biology — are collaborating to develop a “DNA transistor” that could make obtaining a personalized genome analysis easier, faster, and cheaper — ultimately as low as $...

SBE Update: From Idea to Reality

December

2007

SBE Special Section

Engineering Organs: Heart and Esophagus

December

2007

SBE Special Section

Buddy D. Ratner

The potential for tissue engineering to transform the practice of medicine is enormous. Chemical engineers will play important roles in this revolution.

Bioprinting: Directed Tissue Self-Assembly

December

2007

SBE Special Section

Roger Markwald, Vladimir Kasyanov, Vladimir Mironov

Imagine eliminating patient waiting lists for organ transplants. Bioprinting holds the promise of making this happen, but, must research must be done first.

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Molecular, Cellular, & Tissue Engineering

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