Molecular, Cellular, & Tissue Engineering

Singapore: An Emerging Leader in Biomedical Sciences

October
2007
SBE Special Section
Miranda G. S. Yap, Niki S. C. Wong
With a heavy investment in biomedical research— particularly the $330 million to build Biopolis in 2003— Singapore is seeing the fruits of its labor blossom.

Molecular Elucidation and Engineering of Stem Cell Microenvironments

SBE Webinar
Jan 21, 2010

Stem cells are defined by their capacities for self-renewal and differentiation into one or more cell lineages, and these processes are regulated by signals from the stem cell microenvironment, or niche, in various tissues throughout organismal de

Metabolic Flux Analysis of Escherichia Coli MG1655 Under Octanoic Acid Stress

Oct 17, 2011
Yanfen Fu
Metabolic engineering has evolved to the point of fulfilling the dream of having our industrial chemicals produced renewably. Carboxylic acids (e.g., short chain fatty acids (SCFAs) such as octanoic acid (C8)) are one such chemical intermediate that can be produced with Escherichia coli engineered...

Building a Better Biofuel Production Platform

Oct 17, 2011
Stevan Albers
Building a Better Biofuel Production Platform: Engineering metabolic control techniques to control the photosynthetic cyanobacterium Synechocystis sp. PCC 6803 Stevan C. Albers 1 , Christie A.M. Peebles 1,2 1 Cell and Molecular Biology Graduate Program, 2 Department of Chemical and Biological...

 A Microrna Based Synthetic Network as Stable Expression Unit in Mammalian Cells

Nov 7, 2010
Leonidas Bleris
The utility and scalability of complex synthetic gene networks is hampered by fluctuations in stoichiometry between different gene products in individual cells. A critical contribution to the fluctuations arises from variation in the basic transcription efficiency of a gene product that in turn is...

Using Genomic Tools to Improve the Production of Biologics

November
2009
SBE Special Section
Nitya M. Jacob, Wei-Shou Hu, Bernard Liat Wen Loo, and Miranda Yap , Wei shou Hu
Recombinant DNA technology transforms mammalian cells into factories for protein-based therapeutics. New techniques provide chemical engineers with a better understanding of the process as well as the cells themselves.

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