Molecular, Cellular, & Tissue Engineering

Metabolic Flux Analysis of Escherichia Coli MG1655 Under Octanoic Acid Stress

Oct 17, 2011

Yanfen Fu

Metabolic engineering has evolved to the point of fulfilling the dream of having our industrial chemicals produced renewably. Carboxylic acids (e.g., short chain fatty acids (SCFAs) such as octanoic acid (C8)) are one such chemical intermediate that can be produced with Escherichia coli engineered...

Building a Better Biofuel Production Platform

Oct 17, 2011

Stevan Albers

Building a Better Biofuel Production Platform: Engineering metabolic control techniques to control the photosynthetic cyanobacterium Synechocystis sp. PCC 6803 Stevan C. Albers 1 , Christie A.M. Peebles 1,2 1 Cell and Molecular Biology Graduate Program, 2 Department of Chemical and Biological...

Enhanced Xylitol Production Through Simultaneous Co-Consumption of Cellobiose and Xylose by An Engineered Saccharomyces Cerevisiae Strain

Oct 17, 2011

Eun Joong Oh

Xylitol is a five-carbon sugar alcohol and has been used as a sugar substitute in the food industry because of its low caloric and anti-carcinogenic characteristics. In addition, xylitol is a building block for a variety of commodity chemicals. Biological routes for producing xylitol from...

OPTIMIZING IN-VITRO FERTILIZATION TREATMENT: A Pedagogical Case Study of Random Phenomena Analysis

Oct 16, 2011

Babatunde A. Ogunnaike

Engineering practice has always required involvement in the acquisition, analysis, interpretation and exploitation of data in one form or another, so that the “well-educated” engineer ought to be truly conversant with how to handle data. This is even more so today, with many engineers now working...

From Biomass to Biofuels: Breaking the Cellulose Barrier

SBE Webinar

Oct 5, 2011

Douglas Clark

Cellulases are of considerable current interest for converting the cellulosic content of biomass to fermentable sugars for biofuels production.

Tumor Targeting Theory: Physiological Limits from Scaling Analyses, and Design Principles for Better Magic Bullets

SBE Webinar

Sep 26, 2011

K Dane Wittrup

For the past two decades the capability of protein engineers to devise clever tumor-targeting molecules has outstripped our understanding of how these agents distribute through the body and permeate through tumors.

Biomaterials for Stem Cell Tissue Engineering

SBE Webinar

Apr 5, 2011

Dr. Treena Arinzeh

Stem cells have become a promising cell source in the tissue engineering field.

Towards Genome Engineering in Chinese Hamster Ovary Cells

SBE Webinar

Dec 14, 2010

Wei shou Hu

Worth over $30 billion, therapeutic proteins, produced by recombinant mammalian cells, have been the fastest growing class of medicines in industrialized nations.

F-Test in k-Fold Cross Validation and Its Application to the Discovery of Biological Networks

Nov 10, 2010

Mano R. Maurya

There has been considerable emphasis in the recent years on applying systems approaches to decipher and reconstruct cellular networks using high-throughput data. To avoid over-fitting the data and to ensure that the resulting model has good predictive power, cross-validation is often used in data-...

Lung Disease Diagnosis From Gene Expression Profiles

Nov 10, 2010

Shuyi Ma

Lung diseases include some of the most widespread and deadly conditions known to affect people in the US today. One of the main challenges in treating lung disease is the difficulty of diagnosis. Clinical diagnosis remains largely dependent upon symptomatic-based diagnoses; many cases can be either...

Integration of Signaling Networks with Differential Gene Regulation Data Using a Probabilistic Pathway Impact Analysis Approach

Nov 9, 2010

Rajanikanth Vadigepalli

The objective of the present study is to integrate the information on intracellular signaling network structures with large-scale gene expression data sets to predict functional changes in the cellular pathways that are operational under those conditions. Conventional approaches do not consider the...

Identification of Families of Signal Transduction Models Using Pareto Optimal Ensemble Techniques (POETs)

Nov 9, 2010

Anirikh Chakrabarti

Mathematical modeling of complex signal transduction and gene expression programs is an emerging tool for understanding disease mechanisms. However, conventional wisdom suggests that the data requirement to identify and validate complex mechanistic models is too large. Typically, it is not possible...

Probabilistic Integrative Modeling of Genome-Scale Metabolic and Regulatory Networks in Escherichia Coli and Mycobacterium Tuberculosis

Nov 9, 2010

Sriram Chandrasekaran

Systems biology seeks to understand the cell by studying interactions between its various components and the properties that emerge from these interaction networks. The integration of diverse network types has several important applications including diagnosing metabolic disorders and discovering...

Quantitative Modeling and Analysis of TGF-ß-Induced Erk/MAPK and Smad Signaling

Nov 9, 2010

Seung-Wook Chung

Transforming growth factor ß (TGF-ß), which plays a pivotal role in regulating a wide array of cellular and physiologic processes in both normal and pathological cells, is known to function as a potent tumor suppressor during the early stage of tumorigenesis, primarily by inhibiting cell...

Modeling and Analysis of the Retinoic Acid Induced Proliferation and Differentiation Program of HL-60

Nov 9, 2010

Ryan Tasseff

Understanding the molecular basis of differentiation programs is one of the grand unmet challenges facing modern cell-biology. In this study, we integrated computational and experimental network analysis to unravel the response of HL-60 human myeloblastic leukemia cells to Retinoic Acid (RA)...

Gene Regulation by MAPK Substrate Competition

Nov 9, 2010

Yoosik Kim

Introduction Traditional view of pattern formation in the early Drosophila embryo is essentially one-dimensional: The anterior, posterior, and terminal systems initiate the formation of bands and stripes of gene expression along the AP axis; at the same time, the orthogonal gradient of Dorsal (Dl)...

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