Biosensors / Devices

Integration of Signaling Networks with Differential Gene Regulation Data Using a Probabilistic Pathway Impact Analysis Approach

Nov 9, 2010

Rajanikanth Vadigepalli

The objective of the present study is to integrate the information on intracellular signaling network structures with large-scale gene expression data sets to predict functional changes in the cellular pathways that are operational under those conditions. Conventional approaches do not consider the...

Identification of Cell-Type Specific Transcripts for Informative Diagnostics

Nov 8, 2010

Younhee Ko

The identification of cell-type specific or brain-region specific transcripts adds specificity for the diagnosis of a wide variety of brain disorders, such as traumatic brain injury or brain cancers. One goal of identifying cell-type and brain-region specific genes is that they encode for proteins...

Exploring Bistable Molecular Switches and Their Functional Roles Using a Meta-Analysis That Integrates Expression Data with Regulatory Networks

Nov 8, 2010

Ming Wu

An important topic in systems biology is to understand the dynamic properties of the biological networks. Previous studies have provided important insights into the mechanistic principles of dynamic behaviors by applying kinetic modeling to condition-specific and very small networks. However, it...

Directed Evolution of Quorum-Sensing Dependent Transcriptional Repressors for Programmed Intercellular Communication

Nov 7, 2010

Cynthia H. Collins

One of the key challenges in the field of synthetic biology is to engineer not only single cells but also communities of cells that exhibit coordinated, population level behaviors. Synthetic biologists have employed components from acyl-homoserine lactone (AHL)-based quorum-sensing (QS) systems in...

Design and Construction of a Protein Degradation Switch

Nov 7, 2010

S. Marjan Varedi K.

Targeted protein degradation in eukaryotic cells requires recruitment of the target protein to proteasome which is usually triggered by ubiquitination of the target protein. It has recently been shown that ubiquitination is not necessary and localization to the proteasome is sufficient for...

Optofluidic SERS Devices for Biomolecular Detection

Nov 9, 2009

Yun Suk Huh

Recently, Surface-enhanced Raman scattering (SERS) has attracted great attention because of its high sensitivity, label-free detection, and low detection limit. Additionally, it provides a specific fingerprint spectrum of multiplex samples with narrow band width. Because of these advantages, a...

Stability and Reactivity of Enzymatic Papers

Nov 9, 2009

Mohidus Samad Khan

Bioactive papers and paper diagnostics are getting a reality for their low cost, selectivity and application flexibility. Critical is the thermal stability of bioactive papers that need to be shipped and stored. This study quantifies the thermal stability and reactivity of enzymatic bioactive...

DNA Biosensors for the Detection of Hippuricase Gene of Campylobacter Jejuni Based SPREETA and dotLab Platforms

Nov 9, 2009

Tony Gnanaprakasa

DNA-biosensors allow rapid, real-time monitoring of hybridization with the target nucleic acids. These biosensors are gaining more attention over traditional diagnostic methods for their fast and responsive operation, and their cost effective design. Specificity of the system relies on...

Rapid Surface Enhanced Raman Scattering (SERS) Viral Assays

Nov 9, 2009

Patrick A. Johnson

Rapid and accurate detection is the key to controlling the spread of viral pathogens. Recent advances in the field of surface enhanced Raman scattering (SERS) spectroscopy have demonstrated the utility of this technology in diverse research disciplines ranging from surface chemistry and...

Body-on-a-Chip -- A Tool for Predictive Pharmacology/Toxicology

SBE Webinar

Mar 31, 2009

Michael L. Shuler

In this presentation, Professor Mike Shuler details his work to understand the response of the human body to various pharmaceutical and environmental chemicals using a combination of whole body modules and micro models Professor Shuler’s researc

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Biosensors / Devices