Bioprocessing

Keys to Bioreactor Selection

March
2002
Reactions and Separations
John A. Williams
A few basic types of bioreactor designs are used to produce a wide range of products, from antibiotics to foods to fuels. Here's how to pick the best options for your application.

Scaling Up Research to Commercial Manufacturing

November
2010
SBE Special Section
Erika Lapinskas
The production of stem-cell-based therapeutic products in large quantities is more complex than manufacturing molecular drugs. Scale-up and scale-out challenges arise related to the type of stem cell, cell expansion and banking, sterile handling,...

Bioprocess Design for a Novel Vaccine

November
2006
SBE Special Section
Barry C. Buckland
The challenges of vaccine development are not limited to identification of suitable antigens, adjuvants and delivery methods, but include regulatory, technical and manufacturing hurdles in translating a vaccine candidate to the clinic.

Fermentation Goes Large-Scale

January
2003
Special Section
Alex Patist, Aristos Aristidou , J. J. Hahn , Pim van Hoek
Designing an economically competitive and environmentally sustainable fermentation route means considering the downstream separations needed to capture the final product during the initial process design.

Integrating Single-Use Filtration Systems

January
2003
Special Section
Holly Haughney
Disposable filtration systems are gaiing popularity in the pharmaceutical arena. This article defines the equipment, specifications, applications and potential advantages of single-use filters and ancillary equipment.

Bioreactor Design for Chemical Engineers

August
2011
Back To Basics
Gregory T. Benz
Fermentation processes are based on chemical engineering principles. Understand these concepts to achieve optimal bioreactor design.

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